6ZN4
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![BU of 6zn4 by Molmil](/molmil-images/mine/6zn4) | MaeB malic enzyme domain apoprotein | 分子名称: | MAGNESIUM ION, NADP-dependent malate dehydrogenase,Malate dehydrogenase | 著者 | Lovering, A.L, Harding, C.J. | 登録日 | 2020-07-06 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | A rotary mechanism for allostery in bacterial hybrid malic enzymes. Nat Commun, 12, 2021
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7MN5
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![BU of 7mn5 by Molmil](/molmil-images/mine/7mn5) | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-10-27 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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7MN8
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![BU of 7mn8 by Molmil](/molmil-images/mine/7mn8) | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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7MXN
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![BU of 7mxn by Molmil](/molmil-images/mine/7mxn) | PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999 | 分子名称: | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-19 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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7MID
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![BU of 7mid by Molmil](/molmil-images/mine/7mid) | Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | 分子名称: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (33-MER), ... | 著者 | Hu, C.Y, Ke, A.K. | 登録日 | 2021-04-16 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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6ZNK
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6WXZ
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![BU of 6wxz by Molmil](/molmil-images/mine/6wxz) | CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-29 A.K.A 7-(1,2-DIPHENYLETHYL)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(1R)-1,2-diphenylethyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, CALCIUM ION, ... | 著者 | Khan, J.A. | 登録日 | 2020-05-12 | 公開日 | 2020-10-14 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg.Med.Chem., 28, 2020
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7MX7
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![BU of 7mx7 by Molmil](/molmil-images/mine/7mx7) | PRMT5:MEP50 complexed with inhibitor PF-06939999 | 分子名称: | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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7MXA
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![BU of 7mxa by Molmil](/molmil-images/mine/7mxa) | PRMT5:MEP50 complexed with inhibitor PF-06855800 | 分子名称: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.713 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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7MI9
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![BU of 7mi9 by Molmil](/molmil-images/mine/7mi9) | Full integration complex of Cas1/Cas2 from Cas4-containing system | 分子名称: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (5'-D(P*CP*GP*GP*AP*AP*AP*AP*GP*AP*GP*CP*C)-3'), ... | 著者 | Hu, C.Y, Ke, A.K. | 登録日 | 2021-04-16 | 公開日 | 2021-11-17 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MXG
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![BU of 7mxg by Molmil](/molmil-images/mine/7mxg) | PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800 | 分子名称: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-19 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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6ZNT
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![BU of 6znt by Molmil](/molmil-images/mine/6znt) | MaeB PTA domain, acetyl-CoA bound form | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lovering, A.L, Harding, C.J. | 登録日 | 2020-07-06 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | A rotary mechanism for allostery in bacterial hybrid malic enzymes. Nat Commun, 12, 2021
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8EBO
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![BU of 8ebo by Molmil](/molmil-images/mine/8ebo) | |
7MI4
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7MI5
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7MIB
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8BFB
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![BU of 8bfb by Molmil](/molmil-images/mine/8bfb) | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) | 分子名称: | Amyloid-beta precursor protein | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | 登録日 | 2022-10-24 | 公開日 | 2023-05-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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8BFA
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![BU of 8bfa by Molmil](/molmil-images/mine/8bfa) | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure | 分子名称: | Amyloid-beta precursor protein | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | 登録日 | 2022-10-24 | 公開日 | 2023-05-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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7MXC
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![BU of 7mxc by Molmil](/molmil-images/mine/7mxc) | PRMT5:MEP50 complexed with adenosine | 分子名称: | ADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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8DWB
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![BU of 8dwb by Molmil](/molmil-images/mine/8dwb) | |
6LVB
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![BU of 6lvb by Molmil](/molmil-images/mine/6lvb) | Structure of Dimethylformamidase, tetramer | 分子名称: | FE (III) ION, N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit | 著者 | Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. | 登録日 | 2020-02-02 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase. Angew.Chem.Int.Ed.Engl., 59, 2020
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8DQR
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![BU of 8dqr by Molmil](/molmil-images/mine/8dqr) | Crystal structure of Arabidopsis thaliana COSY in complex with scopoletin | 分子名称: | CALCIUM ION, COENZYME A, Coumarin Synthase, ... | 著者 | Kim, C.Y, Mitchell, A.J, Gutierrez, M, Weng, J.K. | 登録日 | 2022-07-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY. Nat Commun, 14, 2023
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7PAB
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![BU of 7pab by Molmil](/molmil-images/mine/7pab) | Varicella zoster Orf24-Orf27 nuclear egress complex | 分子名称: | Nuclear egress protein 2,Nuclear egress protein 1, SULFATE ION, ZINC ION | 著者 | Schweininger, J, Muller, Y.A. | 登録日 | 2021-07-29 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity. J.Biol.Chem., 298, 2022
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7MK7
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![BU of 7mk7 by Molmil](/molmil-images/mine/7mk7) | Augmentor domain of augmentor-beta | 分子名称: | ALK and LTK ligand 1,Maltodextrin-binding protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Krimmer, S.G, Reshetnyak, A.V, Puleo, D.E, Schlessinger, J. | 登録日 | 2021-04-21 | 公開日 | 2021-11-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.42815185 Å) | 主引用文献 | Structural basis for ligand reception by anaplastic lymphoma kinase. Nature, 600, 2021
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6OPV
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![BU of 6opv by Molmil](/molmil-images/mine/6opv) | HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, V82F, I84V Mutant in complex with darunavir | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease NL4-3 | 著者 | Lockbaum, G.J, Henes, M, Kosovrasti, K, Leidner, F, Nachum, G.S, Nalivaika, E.A, Bolon, D.N.A, KurtYilmaz, N, Schiffer, C.A. | 登録日 | 2019-04-25 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance. Acs Chem.Biol., 14, 2019
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