7TAC
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![BU of 7tac by Molmil](/molmil-images/mine/7tac) | Cryo-EM structure of the (TGA3)2-(NPR1)2-(TGA3)2 complex | 分子名称: | PALMITIC ACID, Regulatory protein NPR1, Transcription factor TGA3, ... | 著者 | Wu, Q, Zhou, Y, Bartesaghi, A, Dong, X, Zhou, P. | 登録日 | 2021-12-20 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
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3EJ9
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![BU of 3ej9 by Molmil](/molmil-images/mine/3ej9) | Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity | 分子名称: | Alpha-subunit of trans-3-chloroacrylic acid dehalogenase, Beta-subunit of trans-3-chloroacrylic acid dehalogenase | 著者 | Pegan, S, Serrano, H, Whitman, C.P, Mesecar, A.D. | 登録日 | 2008-09-17 | 公開日 | 2008-12-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallogr.,Sect.D, 64, 2008
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3EJJ
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![BU of 3ejj by Molmil](/molmil-images/mine/3ejj) | Structure of M-CSF bound to the first three domains of FMS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor | 著者 | Chen, X, Liu, H, Focia, P.J, Shim, A, He, X. | 登録日 | 2008-09-18 | 公開日 | 2008-12-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc.Natl.Acad.Sci.USA, 105, 2008
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7SO4
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![BU of 7so4 by Molmil](/molmil-images/mine/7so4) | Crystal Structure of HIV-1 Y181C mutant Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor | 分子名称: | 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | 著者 | Bertoletti, N, Anderson, K.S, Cisneros Trigo, J.A, Jorgensen, W.L, Frey, K.M, Chan, A.H. | 登録日 | 2021-10-29 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9, 2022
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7T47
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![BU of 7t47 by Molmil](/molmil-images/mine/7t47) | KRAS G12D (GppCp) with MRTX-1133 | 分子名称: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, ACETATE ION, GLYCEROL, ... | 著者 | Thomas, N.C, Gunn, R.J, Lawson, J.D, Wang, X, Matthew, M.A. | 登録日 | 2021-12-09 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | A Non-covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of KRAS-dependent Signaling and Regression of KRASG12D-mutant Tumors Nature, 2022
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3EE6
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![BU of 3ee6 by Molmil](/molmil-images/mine/3ee6) | Crystal Structure Analysis of Tripeptidyl peptidase -I | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Pal, A, Kraetzner, R, Grapp, M, Gruene, T, Schreiber, K, Granborg, M, Urlaub, H, Asif, A.R, Becker, S, Gartner, J, Sheldrick, G.M, Steinfeld, R. | 登録日 | 2008-09-04 | 公開日 | 2008-11-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis J.Biol.Chem., 284, 2009
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5KGT
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![BU of 5kgt by Molmil](/molmil-images/mine/5kgt) | Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead: 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone | 分子名称: | 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Maize, K.M, Divakaran, A, Aldrich, C.C, Finzel, B.C. | 登録日 | 2016-06-13 | 公開日 | 2017-06-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. J. Med. Chem., 60, 2017
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3ELK
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![BU of 3elk by Molmil](/molmil-images/mine/3elk) | Crystal structure of putative transcriptional regulator TA0346 from Thermoplasma acidophilum | 分子名称: | CHLORIDE ION, Putative transcriptional regulator TA0346 | 著者 | Grantz Saskova, K, Chruszcz, M, Evdokimova, E, Egorova, O, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2008-09-22 | 公開日 | 2008-09-30 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of putative transcriptional regulator TA0346 from Thermoplasma acidophilum To be Published
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1TG3
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![BU of 1tg3 by Molmil](/molmil-images/mine/1tg3) | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II | 分子名称: | Carbonic anhydrase II, SULFATE ION, ZINC ION | 著者 | Fisher, Z, Hernandez Prada, J.A, Tu, C.K, Duda, D, Yoshioka, C, An, H, Govindasamy, L, Silverman, D.N, McKenna, R. | 登録日 | 2004-05-28 | 公開日 | 2005-01-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II Biochemistry, 44, 2005
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3ENE
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![BU of 3ene by Molmil](/molmil-images/mine/3ene) | Complex of PI3K gamma with an inhibitor | 分子名称: | 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Apsel, B, Blair, J.A, Gonzalez, B.Z, Nazif, T.M, Feldman, M.E, Williams, R.L, Shokat, K.M, Knight, Z.A. | 登録日 | 2008-09-25 | 公開日 | 2008-10-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat.Chem.Biol., 4, 2008
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2IVO
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![BU of 2ivo by Molmil](/molmil-images/mine/2ivo) | Structure of UP1 protein | 分子名称: | TUNGSTATE(VI)ION, UP1 | 著者 | Hecker, A, Leulliot, N, Graille, M, Dorlet, P, Quevillon-Cheruel, S, Ulryck, N, Van Tilbeurgh, H, Forterre, P. | 登録日 | 2006-06-14 | 公開日 | 2007-07-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | An Archaeal Orthologue of the Universal Protein Kae1 is an Iron Metalloprotein which Exhibits Atypical DNA-Binding Properties and Apurinic-Endonuclease Activity in Vitro. Nucleic Acids Res., 35, 2007
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4RDC
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![BU of 4rdc by Molmil](/molmil-images/mine/4rdc) | The crystal structure of a solute-binding protein (N280D mutant) from Anabaena variabilis ATCC 29413 in complex with proline | 分子名称: | Amino acid/amide ABC transporter substrate-binding protein, HAAT family, FORMIC ACID, ... | 著者 | Tan, K, Li, H, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-09-18 | 公開日 | 2014-10-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.198 Å) | 主引用文献 | The crystal structure of a solute-binding protein (N280D mutant) from Anabaena variabilis ATCC 29413 in complex with proline. To be Published
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6W9S
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![BU of 6w9s by Molmil](/molmil-images/mine/6w9s) | |
3EIP
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![BU of 3eip by Molmil](/molmil-images/mine/3eip) | CRYSTAL STRUCTURE OF COLICIN E3 IMMUNITY PROTEIN: AN INHIBITOR TO A RIBOSOME-INACTIVATING RNASE | 分子名称: | PROTEIN (COLICIN E3 IMMUNITY PROTEIN), ZINC ION | 著者 | Li, C, Zhao, D, Djebli, A, Shoham, M. | 登録日 | 1999-03-29 | 公開日 | 1999-11-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of colicin E3 immunity protein: an inhibitor of a ribosome-inactivating RNase. Structure Fold.Des., 7, 1999
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1TKG
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![BU of 1tkg by Molmil](/molmil-images/mine/1tkg) | Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with an analog of seryladenylate | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase | 著者 | Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D. | 登録日 | 2004-06-08 | 公開日 | 2004-11-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution. Mol.Cell, 16, 2004
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5KEQ
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![BU of 5keq by Molmil](/molmil-images/mine/5keq) | High resolution cryo-EM maps of Human papillomavirus 16 reveal L2 location and heparin-induced conformational changes | 分子名称: | Major capsid protein L1 | 著者 | Guan, J, Bywaters, S.M, Brendle, S.A, Ashley, R.E, Makhov, A.M, Conway, J.F, Christensen, N.D, Hafenstein, S. | 登録日 | 2016-06-10 | 公開日 | 2017-01-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site. Structure, 25, 2017
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2WA9
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![BU of 2wa9 by Molmil](/molmil-images/mine/2wa9) | Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS - Trp peptide structure | 分子名称: | ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS, TRP PEPTIDE | 著者 | Schuenemann, V.J, Kralik, S.M, Albrecht, R, Spall, S.K, Truscott, K.N, Dougan, D.A, Zeth, K. | 登録日 | 2009-02-03 | 公開日 | 2009-04-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Basis of N-End Rule Substrate Recognition in Escherichia Coli by the Clpap Adaptor Protein Clps. Embo Rep., 10, 2009
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6WAT
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![BU of 6wat by Molmil](/molmil-images/mine/6wat) | complex structure of PHF1 | 分子名称: | Histone H3.1t peptide, PHD finger protein 1, UNKNOWN ATOM OR ION | 著者 | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-26 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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1TH9
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![BU of 1th9 by Molmil](/molmil-images/mine/1th9) | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II | 分子名称: | Carbonic anhydrase II, SULFATE ION, ZINC ION | 著者 | Fisher, Z, Hernandez Prada, J.A, Tu, C.K, Duda, D, Yoshioka, C, An, H, Govindasamy, L, Silverman, D.N, McKenna, R. | 登録日 | 2004-06-01 | 公開日 | 2005-01-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II Biochemistry, 44, 2005
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7AQT
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![BU of 7aqt by Molmil](/molmil-images/mine/7aqt) | NMR2 structure of BRD4-BD2 in complex with iBET-762 | 分子名称: | 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, Bromodomain-containing protein 4 | 著者 | Orts, J, Torres, F, Milbradt, A.G, Walser, R. | 登録日 | 2020-10-23 | 公開日 | 2022-03-02 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24. J.Med.Chem., 65, 2022
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6IVJ
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![BU of 6ivj by Molmil](/molmil-images/mine/6ivj) | Crystal structure of a membrane protein G18A | 分子名称: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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3E22
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![BU of 3e22 by Molmil](/molmil-images/mine/3e22) | Tubulin-colchicine-soblidotin: Stathmin-like domain complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B. | 登録日 | 2008-08-05 | 公開日 | 2008-10-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural insight into the inhibition of tubulin by vinca domain peptide ligands Embo Rep., 9, 2008
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3E30
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![BU of 3e30 by Molmil](/molmil-images/mine/3e30) | |
1TIU
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![BU of 1tiu by Molmil](/molmil-images/mine/1tiu) | TITIN, IG REPEAT 27, NMR, 24 STRUCTURES | 分子名称: | TITIN, I27 | 著者 | Improta, S, Politou, A.S, Pastore, A. | 登録日 | 1996-02-02 | 公開日 | 1996-07-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity. Structure, 4, 1996
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5KH7
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![BU of 5kh7 by Molmil](/molmil-images/mine/5kh7) | Crystal structure of fragment (3-[6-Oxo-3-(3-pyridinyl)-1(6H)-pyridazinyl]propanoic acid) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain | 分子名称: | 3-(6-oxidanylidene-3-pyridin-3-yl-pyridazin-1-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... | 著者 | Harding, R.J, Walker, J, Ravichandran, M, Ferreira de Freitas, R, Schapira, M, Bountra, C, Edwards, A.M, Santhakumar, V, Arrowsmith, C.M, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-14 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. J. Med. Chem., 60, 2017
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