Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7T47

KRAS G12D (GppCp) with MRTX-1133

Summary for 7T47
Entry DOI10.2210/pdb7t47/pdb
Related7RPZ
DescriptorGTPase KRas, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (8 entities in total)
Functional Keywordsoncoprotein, g12d, gcp, gtpase, kras4b, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight23305.60
Authors
Thomas, N.C.,Gunn, R.J.,Lawson, J.D.,Wang, X.,Matthew, M.A. (deposition date: 2021-12-09, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citationChristensen, J.,Hallin, J.,Bowcut, V.,Calinsan, A.,Briere, D.,Hargis, L.,Engstrom, L.,Laguer, J.,Medwid, J.,Vanderpool, D.,Lifset, E.,Trinh, D.,Hoffman, N.,Wang, X.,Lawson, J.,Gunn, R.,Smith, C.,Thomas, N.,Martinson, M.,Bergstrom, A.,Sullivan, F.,Bouhana, K.,Winski, S.,He, L.,Julio, F.B.,Pavlicek, A.,Hafing, J.,Rahbaek, L.,Marx, M.,Olson, P.
A Non-covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of KRAS-dependent Signaling and Regression of KRASG12D-mutant Tumors
Nature, 2022
Cited by
DOI: 10.21203/rs.3.rs-1261963/v1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.27 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon