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5KH7

Crystal structure of fragment (3-[6-Oxo-3-(3-pyridinyl)-1(6H)-pyridazinyl]propanoic acid) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Summary for 5KH7
Entry DOI10.2210/pdb5kh7/pdb
Related5B8D 5KH3 5KH9
DescriptorHistone deacetylase 6, ZINC ION, 3-(6-oxidanylidene-3-pyridin-3-yl-pyridazin-1-yl)propanoic acid, ... (5 entities in total)
Functional Keywordshistone deacetylase, hdac, hdac6, fragment screening, structural genomics consortium, sgc, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight12374.07
Authors
Primary citationHarding, R.J.,Ferreira de Freitas, R.,Collins, P.,Franzoni, I.,Ravichandran, M.,Ouyang, H.,Juarez-Ornelas, K.A.,Lautens, M.,Schapira, M.,von Delft, F.,Santhakumar, V.,Arrowsmith, C.H.
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60:9090-9096, 2017
Cited by
PubMed: 29019676
DOI: 10.1021/acs.jmedchem.7b00933
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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