4RGZ
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![BU of 4rgz by Molmil](/molmil-images/mine/4rgz) | Crystal structure of recombinant prolidase from Thermococcus sibiricus at P21221 spacegroup | 分子名称: | PHOSPHATE ION, Xaa-Pro aminopeptidase, ZINC ION | 著者 | Timofeev, V.I, Korgenevsky, D.A, Gorbacheva, M.A, Boyko, K.M, Slutsky, E, Rakitina, T.V, Lipkin, A.V, Popov, V.O. | 登録日 | 2014-10-01 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of recombinant prolidase from Thermococcus sibiricus in space group P21221. Acta Crystallogr.,Sect.F, 71, 2015
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1TGO
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![BU of 1tgo by Molmil](/molmil-images/mine/1tgo) | THERMOSTABLE B TYPE DNA POLYMERASE FROM THERMOCOCCUS GORGONARIUS | 分子名称: | PROTEIN (THERMOSTABLE B DNA POLYMERASE) | 著者 | Hopfner, K.-P, Eichinger, A, Engh, R.A, Laue, F, Ankenbauer, W, Huber, R, Angerer, B. | 登録日 | 1999-02-23 | 公開日 | 1999-03-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. Proc.Natl.Acad.Sci.USA, 96, 1999
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8A1M
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![BU of 8a1m by Molmil](/molmil-images/mine/8a1m) | Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with maleimide analogue 4 | 分子名称: | 1,2-ETHANEDIOL, 1-(2-fluoranyl-5-methylsulfonyl-phenyl)pyrrolidine-2,5-dione, CHLORIDE ION, ... | 著者 | de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J. | 登録日 | 2022-06-01 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chem Sci, 14, 2023
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5KLV
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![BU of 5klv by Molmil](/molmil-images/mine/5klv) | Structure of bos taurus cytochrome bc1 with fenamidone inhibited | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | 著者 | Xia, D, Esser, L, Zhou, F, Zhou, Y, Xiao, Y, Tang, W.K, Yu, C.A, Qin, Z. | 登録日 | 2016-06-25 | 公開日 | 2016-10-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.652 Å) | 主引用文献 | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III. J.Biol.Chem., 291, 2016
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5KO0
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![BU of 5ko0 by Molmil](/molmil-images/mine/5ko0) | Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED | 分子名称: | THIOCYANATE ION, hIAPP(15-25)WT | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | 登録日 | 2016-06-28 | 公開日 | 2016-12-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity. Elife, 6, 2017
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6PU4
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![BU of 6pu4 by Molmil](/molmil-images/mine/6pu4) | MicroED structure of proteinase K recorded on Falcon III | 分子名称: | CALCIUM ION, Proteinase K | 著者 | Hattne, J, Martynowycz, M.W, Penzcek, P.A, Gonen, T. | 登録日 | 2019-07-17 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | 主引用文献 | MicroED with the Falcon III direct electron detector. Iucrj, 6, 2019
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8A1R
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![BU of 8a1r by Molmil](/molmil-images/mine/8a1r) | cryo-EM structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-[3-[[[(1~{R},2~{R},3~{R},5~{S})-2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]amino]methyl]indol-1-yl]oxane-3,4,5-triol, FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin glutathione reductase | 著者 | Ardini, M, Angelucci, F, Fata, F, Gabriele, F, Effantin, G, Ling, W, Williams, D.L, Petukhova, V.Z, Petukhov, P.A. | 登録日 | 2022-06-01 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun, 14, 2023
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1K4M
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![BU of 1k4m by Molmil](/molmil-images/mine/1k4m) | Crystal structure of E.coli nicotinic acid mononucleotide adenylyltransferase complexed to deamido-NAD | 分子名称: | CITRIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NaMN adenylyltransferase | 著者 | Zhang, H, Zhou, T, Kurnasov, O, Cheek, S, Grishin, N.V, Osterman, A. | 登録日 | 2001-10-08 | 公開日 | 2002-10-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure, 10, 2002
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8A1J
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![BU of 8a1j by Molmil](/molmil-images/mine/8a1j) | Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with maleimide analogue 3 | 分子名称: | 1,2-ETHANEDIOL, 1-phenylpyrrolidine-2,5-dione, DIMETHYL SULFOXIDE, ... | 著者 | de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J. | 登録日 | 2022-06-01 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chem Sci, 14, 2023
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7SQO
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![BU of 7sqo by Molmil](/molmil-images/mine/7sqo) | Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | McGrath, A.P, Kang, Y, Flinspach, M. | 登録日 | 2021-11-05 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7T7N
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![BU of 7t7n by Molmil](/molmil-images/mine/7t7n) | Structure of SPCC1393.13 protein from fission yeast | 分子名称: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, Damage-control phosphatase SPCC1393.13, PHOSPHATE ION | 著者 | Jacewicz, A, Sanchez, A.M, Shuman, S. | 登録日 | 2021-12-15 | 公開日 | 2022-06-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J.Biol.Chem., 298, 2022
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5KOS
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![BU of 5kos by Molmil](/molmil-images/mine/5kos) | Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-~{tert}-butyl-4-(3-methoxypropylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]pyrimidine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ... | 著者 | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.-C, Lane, W. | 登録日 | 2016-07-01 | 公開日 | 2016-11-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. Acs Med.Chem.Lett., 7, 2016
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4RIL
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![BU of 4ril by Molmil](/molmil-images/mine/4ril) | Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | 分子名称: | Alpha-synuclein | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | 登録日 | 2014-10-06 | 公開日 | 2015-08-26 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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7ZYT
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![BU of 7zyt by Molmil](/molmil-images/mine/7zyt) | Crystal structure of the I318T pathogenic variant of the human dihydrolipoamide dehydrogenase | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, ... | 著者 | Nemes-Nikodem, E, Szabo, E, Vass, K.R, Lennartz, F, Nagy, B, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | 登録日 | 2022-05-25 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.892 Å) | 主引用文献 | Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase. Int J Mol Sci, 24, 2023
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5KNI
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![BU of 5kni by Molmil](/molmil-images/mine/5kni) | |
7TBI
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![BU of 7tbi by Molmil](/molmil-images/mine/7tbi) | Composite structure of the S. cerevisiae nuclear pore complex (NPC) | 分子名称: | Dyn2, Nic96 R1, Nic96 R2, ... | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-12-22 | 公開日 | 2022-06-15 | 最終更新日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (25 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
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6WCF
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![BU of 6wcf by Molmil](/molmil-images/mine/6wcf) | Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Non-structural protein 3 | 著者 | Michalska, K, Kim, Y, Jedrzejczak, R, Maltseva, N, Endres, M, Mesecar, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-03-30 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.065 Å) | 主引用文献 | Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes. Iucrj, 7, 2020
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7SQ1
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![BU of 7sq1 by Molmil](/molmil-images/mine/7sq1) | BG505.MD39TS Env trimer in complex with Fab from antibody C05 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C05 Fab Light chain, ... | 著者 | Moore, A, Du, J, Xu, Z, Walker, S, Kulp, D.W, Pallesen, J. | 登録日 | 2021-11-04 | 公開日 | 2022-06-22 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer. Nat Commun, 13, 2022
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6PX5
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![BU of 6px5 by Molmil](/molmil-images/mine/6px5) | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | 登録日 | 2019-07-24 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Sci Rep, 9, 2019
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2IOH
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![BU of 2ioh by Molmil](/molmil-images/mine/2ioh) | Crystal structure of phosphonoacetaldehyde hydrolase with a K53R mutation | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, Phosphonoacetaldehyde hydrolase | 著者 | Allen, K.A, Lahiri, S.D, Zhang, G, Dunaway-Mariano, D, Peisach, E. | 登録日 | 2006-10-10 | 公開日 | 2007-08-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage. Bioorg.Chem., 34, 2006
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7TBP
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![BU of 7tbp by Molmil](/molmil-images/mine/7tbp) | X-ray structure of the HIV-1 myristoylated matrix protein | 分子名称: | CITRIC ACID, Capsid protein p24, MYRISTIC ACID, ... | 著者 | Green, T.J, Saad, J.S, Samal, A.B. | 登録日 | 2021-12-22 | 公開日 | 2022-06-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation. Proc.Natl.Acad.Sci.USA, 119, 2022
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1T4G
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![BU of 1t4g by Molmil](/molmil-images/mine/1t4g) | ATPase in complex with AMP-PNP | 分子名称: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Wu, Y, He, Y, Moya, I.A, Qian, X, Luo, Y. | 登録日 | 2004-04-29 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Archaeal Recombinase RadA; A Snapshot of Its Extended Conformation. Mol.Cell, 15, 2004
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2J7A
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![BU of 2j7a by Molmil](/molmil-images/mine/2j7a) | Crystal structure of cytochrome c nitrite reductase NrfHA complex from Desulfovibrio vulgaris | 分子名称: | ACETATE ION, CALCIUM ION, CYTOCHROME C NITRITE REDUCTASE NRFA, ... | 著者 | Rodrigues, M.L, Oliveira, T.F, Pereira, I.A.C, Archer, M. | 登録日 | 2006-10-06 | 公開日 | 2006-12-06 | 最終更新日 | 2019-11-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | X-Ray Structure of the Membrane-Bound Cytochrome C Quinol Dehydrogenase Nrfh Reveals Novel Haem Coordination. Embo J., 25, 2006
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4RAT
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![BU of 4rat by Molmil](/molmil-images/mine/4rat) | |
2ID2
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![BU of 2id2 by Molmil](/molmil-images/mine/2id2) | GAPN T244S mutant X-ray structure at 2.5 A | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, SULFATE ION | 著者 | Pailot, A, D'Ambrosio, K, Corbier, C, Talfournier, F, Branlant, G. | 登録日 | 2006-09-14 | 公開日 | 2007-09-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. Biochem.J., 400, 2006
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