5KOS

Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor

Summary for 5KOS

Entry DOI	10.2210/pdb5kos/pdb
Related	5KOQ 5KOT
Descriptor	Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-~{tert}-butyl-4-(3-methoxypropylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]pyrimidine-5-carboxamide, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	76458.68
Authors	Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.-C.,Lane, W. (deposition date: 2016-07-01, release date: 2016-11-16, Last modification date: 2020-07-29)
Primary citation	Imaeda, Y.,Tokuhara, H.,Fukase, Y.,Kanagawa, R.,Kajimoto, Y.,Kusumoto, K.,Kondo, M.,Snell, G.,Behnke, C.A.,Kuroita, T. Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. Acs Med.Chem.Lett., 7:933-938, 2016 Cited by PubMed: 27774132 DOI: 10.1021/acsmedchemlett.6b00251 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation