8GAF
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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7U0B
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6PU6
| CobT from Methanocaldococcus jannaschii in complex with Alpha-Ribozole 5'-Phosphate, Nicotinic Acid, and Nicotinic Acid Mononucleotide | 分子名称: | ALPHA-RIBAZOLE-5'-PHOSPHATE, NICOTINATE MONONUCLEOTIDE, NICOTINIC ACID, ... | 著者 | Schwarzwalder, A.H, Jeter, V.L, Vecellio, A.A, Erpenbach, E, Escalante-Semerena, J.C, Rayment, I. | 登録日 | 2019-07-17 | 公開日 | 2020-07-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.293 Å) | 主引用文献 | Structural studies of the phosphoribosyltransferase involved in cobamide biosynthesis in methanogenic archaea and cyanobacteria. Sci Rep, 12, 2022
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8QAR
| Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98 | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, Bromodomain-containing protein 4 | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | 登録日 | 2023-08-23 | 公開日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines To be published
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4TXW
| Crystal structure of CBM32-4 from the Clostridium perfringens NagH | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Hyaluronoglucosaminidase | 著者 | Grondin, J.M, Ficko-Blean, E, Boraston, A.B, Smith, S.P. | 登録日 | 2014-07-07 | 公開日 | 2015-12-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Solution Structure and Dynamics of Full-length GH84A, a multimodular B-N-acetylglucosaminidase from Clostridium perfringens To Be Published
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5KDR
| The crystal structure of carboxyltransferase from Staphylococcus Aureus bound to the antimicrobial agent moiramide B. | 分子名称: | 1,2-ETHANEDIOL, Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ... | 著者 | Silvers, M.A, Pakhomova, S, Neau, D, Silvers, W.C, Anzalone, N, Taylor, C.M, Waldrop, G.L. | 登録日 | 2016-06-08 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B. Biochemistry, 55, 2016
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6G3A
| Crystal structure of haspin F605T mutant in complex with 5-iodotubercidin | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, DIMETHYL SULFOXIDE, IODIDE ION, ... | 著者 | Heroven, C, Chaikuad, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2018-03-24 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times. Angew. Chem. Int. Ed. Engl., 57, 2018
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6I0K
| Structure of quinolinate synthase in complex with 4-mercaptophthalic acid | 分子名称: | 4-mercaptoidenecyclohexa-2,5-diene-1,2-dicarboxylic acid, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | 著者 | Volbeda, A, Fontecilla-Camps, J.C. | 登録日 | 2018-10-26 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chem.Commun.(Camb.), 55, 2019
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6MQ3
| Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol | 著者 | Tan, G.A, Seeliger, M.A, Welsh, A.J, Maianti, J.P, Liu, D.R. | 登録日 | 2018-10-09 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.569147 Å) | 主引用文献 | Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15, 2019
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6HI8
| The ATAD2 bromodomain in complex with compound 11 | 分子名称: | 2-azanyl-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]-2-methyl-propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION | 著者 | Sledz, P, Caflisch, A. | 登録日 | 2018-08-29 | 公開日 | 2019-10-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers. Acs Med.Chem.Lett., 11, 2020
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6BPS
| Crystal structure of cysteine-bound ferrous form of the uncrosslinked F2-Tyr157 human cysteine dioxygenase | 分子名称: | CYSTEINE, Cysteine dioxygenase type 1, FE (II) ION, ... | 著者 | Liu, A, Li, J, Shin, I. | 登録日 | 2017-11-26 | 公開日 | 2018-07-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat. Chem. Biol., 14, 2018
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8Q5R
| HpARI bound to mouse IL-33 | 分子名称: | 1,2-ETHANEDIOL, Alarmin release inhibitor, CHLORIDE ION, ... | 著者 | Jamwal, A, Higgins, M.K. | 登録日 | 2023-08-09 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nat Commun, 15, 2024
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7RXH
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4ZN7
| Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol | 分子名称: | DIETHYLSTILBESTROL, Estrogen receptor, Nuclear receptor coactivator 2 | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-04 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.934 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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6W4S
| Structure of apo human ferroportin in lipid nanodisc | 分子名称: | Fab45D8 Heavy Chain, Fab45D8 Light Chain, Solute carrier family 40 member 1 | 著者 | Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A. | 登録日 | 2020-03-11 | 公開日 | 2020-09-09 | 最終更新日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature, 586, 2020
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6HJL
| Affimer:BclxL | 分子名称: | Affimer ADB13, Bcl-2-like protein 1 | 著者 | Miles, J.A, Trinh, C.H, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | 登録日 | 2018-09-04 | 公開日 | 2020-03-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs Biorxiv, 2020
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8OO9
| CryoEM Structure INO80core Hexasome complex ATPase-DNA refinement state1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chromatin-remodeling ATPase INO80, DNA strand 1, ... | 著者 | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | 登録日 | 2023-04-04 | 公開日 | 2023-07-26 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling. Science, 381, 2023
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8OOF
| CryoEM Structure INO80core Hexasome complex Arp5 Ies6 refinement state1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling complex subunit IES6, ... | 著者 | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | 登録日 | 2023-04-05 | 公開日 | 2023-07-26 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling. Science, 381, 2023
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6BO0
| MdbA protein, a thiol-disulfide oxidoreductase from Corynebacterium matruchotii | 分子名称: | MdbA protein, TETRAETHYLENE GLYCOL | 著者 | Osipiuk, J, Luong, T.Y, Trigar, R, Ton-That, H, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-11-17 | 公開日 | 2017-12-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural Basis of a Thiol-Disulfide Oxidoreductase in the Hedgehog-Forming Actinobacterium Corynebacterium matruchotii. J. Bacteriol., 200, 2018
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4ZOE
| Crystal Structure of beta-glucosidase from Listeria innocua | 分子名称: | GLYCEROL, Lin1840 protein, MAGNESIUM ION | 著者 | Nakajima, M, Yoshida, R, Miyanaga, A, Abe, K, Takahashi, Y, Sugimoto, N, Toyoizumi, H, Nakai, H, Kitaoka, M, Taguchi, H. | 登録日 | 2015-05-06 | 公開日 | 2016-05-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Functional and Structural Analysis of a beta-Glucosidase Involved in beta-1,2-Glucan Metabolism in Listeria innocua Plos One, 11, 2016
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7K8U
| Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C104 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C104 Fab Heavy Chain, ... | 著者 | Barnes, C.O, Malyutin, A.G, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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6HKM
| Crystal structure of Compound 1 with ERK5 | 分子名称: | Mitogen-activated protein kinase 7, [4-(6,7-dimethoxyquinazolin-4-yl)piperidin-1-yl]-[4-(trifluoromethyloxy)phenyl]methanone | 著者 | Nguyen, D, Lemos, C, Wortmann, L, Eis, K, Holton, S.J, Boemer, U, Lechner, C, Prechtl, S, Suelze, D, Siegel, F, Prinz, F, Lesche, R, Nicke, B, Mumberg, D, Bauser, M, Haegebarth, A. | 登録日 | 2018-09-07 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J. Med. Chem., 62, 2019
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4ZIE
| Crystal Structure of core/latch dimer of Bax in complex with BimBH3 | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2-like protein 11 | 著者 | Krishna Kumar, K, Robin, A.Y, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | 登録日 | 2015-04-28 | 公開日 | 2015-07-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | 主引用文献 | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. Cell Death Dis, 6, 2015
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6H8X
| Beta-phosphoglucomutase from Lactococcus lactis in an open conformer complexed with magnesium trifluoride to 1.8 A. | 分子名称: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, ACETATE ION, ... | 著者 | Robertson, A.J, Bisson, C, Waltho, J.P. | 登録日 | 2018-08-03 | 公開日 | 2020-08-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Transition state of phospho-enzyme hydrolysis in beta-phosphoglucomutase. To Be Published
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4ZQ8
| Crystal structure of a terpene synthase from Streptomyces lydicus, target EFI-540129 | 分子名称: | Isoprenoid Synthase | 著者 | Toro, R, Bhosle, R, Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Poulter, C.D, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2015-05-08 | 公開日 | 2015-07-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a terpene synthase from Streptomyces lydicus, target EFI-540129 To be published
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