8QAR

Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98

Summary for 8QAR

• Entry DOI: 10.2210/pdb8qar/pdb
• Related: 7QZB 8QAL 8QAN 8QAP
• Descriptor: Bromodomain-containing protein 4, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15634.05

Authors

Dalle Vedove, A.,Cazzanelli, G.,Lolli, G. (deposition date: 2023-08-23, release date: 2024-09-11)

• Primary citation: Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G.; Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines; To be published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)