8QAN

Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 79

Summary for 8QAN

• Entry DOI: 10.2210/pdb8qan/pdb
• Related: 7QYO 8QAL
• Descriptor: Bromodomain-containing protein 4, 1-[2-methyl-4-(3-methylbutyl)-5-(2-piperazin-1-yl-1,3-thiazol-4-yl)-1~{H}-pyrrol-3-yl]ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15521.96

Authors

Dalle Vedove, A.,Cazzanelli, G.,Lolli, G. (deposition date: 2023-08-23, release date: 2024-09-11)

• Primary citation: Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G.; Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines; To be published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)