6G3A
Crystal structure of haspin F605T mutant in complex with 5-iodotubercidin
Summary for 6G3A
Entry DOI | 10.2210/pdb6g3a/pdb |
Related | 6g34 |
Descriptor | Serine/threonine-protein kinase haspin, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (6 entities in total) |
Functional Keywords | kinase, inhibitors, slow off-rate, kinetics, halogen, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41484.48 |
Authors | Heroven, C.,Chaikuad, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-03-24, release date: 2018-04-18, Last modification date: 2024-01-17) |
Primary citation | Heroven, C.,Georgi, V.,Ganotra, G.K.,Brennan, P.,Wolfreys, F.,Wade, R.C.,Fernandez-Montalvan, A.E.,Chaikuad, A.,Knapp, S. Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times. Angew. Chem. Int. Ed. Engl., 57:7220-7224, 2018 Cited by PubMed: 29601130DOI: 10.1002/anie.201801666 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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