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6G3A

Crystal structure of haspin F605T mutant in complex with 5-iodotubercidin

Summary for 6G3A
Entry DOI10.2210/pdb6g3a/pdb
Related6g34
DescriptorSerine/threonine-protein kinase haspin, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (6 entities in total)
Functional Keywordskinase, inhibitors, slow off-rate, kinetics, halogen, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight41484.48
Authors
Heroven, C.,Chaikuad, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-03-24, release date: 2018-04-18, Last modification date: 2024-01-17)
Primary citationHeroven, C.,Georgi, V.,Ganotra, G.K.,Brennan, P.,Wolfreys, F.,Wade, R.C.,Fernandez-Montalvan, A.E.,Chaikuad, A.,Knapp, S.
Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.
Angew. Chem. Int. Ed. Engl., 57:7220-7224, 2018
Cited by
PubMed: 29601130
DOI: 10.1002/anie.201801666
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.43 Å)
Structure validation

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