4ZN7

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol

Summary for 4ZN7

Entry DOI	10.2210/pdb4zn7/pdb
Related	4PP6 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, DIETHYLSTILBESTROL, ... (4 entities in total)
Functional Keywords	nuclear receptor transcription factor nucleus protein-ligand complex, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	62355.35
Authors	Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (deposition date: 2015-05-04, release date: 2016-05-04, Last modification date: 2023-09-27)
Primary citation	Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12:864-864, 2016 Cited by PubMed: 27107013 DOI: 10.15252/msb.20156701 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.934 Å)

Structure validation