4ZN7
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 259 | 29329.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | C, D | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
3 | A, B | DIETHYLSTILBESTROL | non-polymer | 268.4 | 2 | Chemie (DES) | |||
4 | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 301 - 559 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 61818.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 536.7 | |
All* | Total formula weight | 62355.3 |