6LPP
| Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-2-hydroxyglutarate (D-2-HG) | Descriptor: | (2R)-2-hydroxypentanedioic acid, D-2-hydroxyglutarate dehydrogenase, mitochondrial, ... | Authors: | Yang, J, Zhu, H, Ding, J. | Deposit date: | 2020-01-12 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7, 2021
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6LPU
| Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with L-2-hydroxyglutarate (L-2-HG) | Descriptor: | (2S)-2-HYDROXYPENTANEDIOIC ACID, D-2-hydroxyglutarate dehydrogenase, mitochondrial, ... | Authors: | Yang, J, Zhu, H, Ding, J. | Deposit date: | 2020-01-12 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.923 Å) | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7, 2021
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6LT0
| cryo-EM structure of C9ORF72-SMCR8-WDR41 | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | Authors: | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | Deposit date: | 2020-01-21 | Release date: | 2020-04-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
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7EN3
| Crystal structure of tubulin in complex with Tubulysin analogue TGL | Descriptor: | (2S,4R)-5-(4-fluorophenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[5-methylhexyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-1-oxidanyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Li, W. | Deposit date: | 2021-04-15 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.643 Å) | Cite: | The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues. Biochem.Biophys.Res.Commun., 565, 2021
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6LPQ
| Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-malate (D-MAL) | Descriptor: | D-2-hydroxyglutarate dehydrogenase, mitochondrial, D-MALATE, ... | Authors: | Yang, J, Zhu, H, Ding, J. | Deposit date: | 2020-01-12 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7, 2021
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6LPN
| Crystal structure of human D-2-hydroxyglutarate dehydrogenase in apo form | Descriptor: | D-2-hydroxyglutarate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Yang, J, Zhu, H, Ding, J. | Deposit date: | 2020-01-12 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7, 2021
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6LPT
| Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-lactate (D-LAC) | Descriptor: | D-2-hydroxyglutarate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yang, J, Zhu, H, Ding, J. | Deposit date: | 2020-01-12 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.621 Å) | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7, 2021
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7VRA
| The crystal structure of EGFR T790M/C797S with the inhibitor HC5476 | Descriptor: | 25-chloro-11-(ethylsulfonyl)-44-morpholino-11H-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane, Epidermal growth factor receptor | Authors: | Zhu, S.J. | Deposit date: | 2021-10-22 | Release date: | 2022-06-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J.Med.Chem., 65, 2022
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7VRE
| The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892 | Descriptor: | 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine, Epidermal growth factor receptor | Authors: | Zhu, S.J. | Deposit date: | 2021-10-22 | Release date: | 2022-06-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J.Med.Chem., 65, 2022
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7WXG
| GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXF
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7WXI
| GPR domain of Drosophila P5CS filament with glutamate and ATPgammaS | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXH
| GPR domain open form of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WX4
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7WX3
| GK domain of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE, ... | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WBG
| BF2*1901/RY8 | Descriptor: | ARG-ARG-ARG-GLU-GLN-THR-ASP-TYR, Beta-2-microglobulin, MHC class I alpha chain 2 | Authors: | Liu, W.J. | Deposit date: | 2021-12-16 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol., 210, 2023
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7WBI
| BF2*1901-FLU | Descriptor: | Beta-2-microglobulin, ILE-ARG-HIS-GLU-ASN-ARG-MET-VAL-LEU, MHC class I alpha chain 2 | Authors: | Liu, W.J. | Deposit date: | 2021-12-16 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol., 210, 2023
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7XJP
| Cryo-EM structure of EDS1 and SAG101 with ATP-APDR | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ISOPROPYL ALCOHOL, ... | Authors: | Huang, S.J, Jia, A.L, Han, Z.F, Chai, J.J. | Deposit date: | 2022-04-18 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science, 377, 2022
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7XN3
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi | Descriptor: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-27 | Release date: | 2022-06-29 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XMV
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A(AMP/ADP) filament bound with ADP, AMP and R5P | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-27 | Release date: | 2022-06-29 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XMU
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-26 | Release date: | 2022-06-29 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XA4
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7X9X
| Thermotoga Maritima ferritin variant-Tm-E(G40E) with Zn | Descriptor: | FE (III) ION, Ferritin, ZINC ION | Authors: | Liu, Y, Zhao, G. | Deposit date: | 2022-03-16 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Directed Self-Assembly of Dimeric Building Blocks into Networklike Protein Origami to Construct Hydrogels. Acs Nano, 16, 2022
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7XA2
| Thermotoga maritima ferritin variant-Tm-E(S111H) | Descriptor: | FE (III) ION, Ferritin | Authors: | Liu, Y, Zhao, G. | Deposit date: | 2022-03-16 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Directed Self-Assembly of Dimeric Building Blocks into Networklike Protein Origami to Construct Hydrogels. Acs Nano, 16, 2022
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7XOZ
| Crystal structure of RPPT-TIR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | Authors: | Song, W, Jia, A, Huang, S, Chai, J. | Deposit date: | 2022-05-02 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science, 377, 2022
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