7EN3
Crystal structure of tubulin in complex with Tubulysin analogue TGL
Summary for 7EN3
Entry DOI | 10.2210/pdb7en3/pdb |
Descriptor | Tubulin alpha-1B chain, (2S,4R)-5-(4-fluorophenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[5-methylhexyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-1-oxidanyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 6 |
Total formula weight | 265622.38 |
Authors | |
Primary citation | Li, W.,Tan, L.,Zhang, Z.,Xia, Q.,Lei, D.,Li, Y.,Zhang, T.,Zeng, S.,Sima, X.,Wang, Y. The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues. Biochem.Biophys.Res.Commun., 565:29-35, 2021 Cited by PubMed: 34090207DOI: 10.1016/j.bbrc.2021.05.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.643 Å) |
Structure validation
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