7EN3

Crystal structure of tubulin in complex with Tubulysin analogue TGL

Summary for 7EN3

• Entry DOI: 10.2210/pdb7en3/pdb
• Descriptor: Tubulin alpha-1B chain, (2S,4R)-5-(4-fluorophenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[5-methylhexyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-1-oxidanyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 6
• Total formula weight: 265622.38

Authors

Wang, Y.,Li, W. (deposition date: 2021-04-15, release date: 2022-04-27, Last modification date: 2023-11-29)

• Primary citation: Li, W.,Tan, L.,Zhang, Z.,Xia, Q.,Lei, D.,Li, Y.,Zhang, T.,Zeng, S.,Sima, X.,Wang, Y.; The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues.; Biochem.Biophys.Res.Commun., 565:29-35, 2021; PubMed: 34090207; DOI: 10.1016/j.bbrc.2021.05.086

Experimental method

X-RAY DIFFRACTION (2.643 Å)