7VRA

The crystal structure of EGFR T790M/C797S with the inhibitor HC5476

Summary for 7VRA

Entry DOI	10.2210/pdb7vra/pdb
Descriptor	Epidermal growth factor receptor, 25-chloro-11-(ethylsulfonyl)-44-morpholino-11H-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane (3 entities in total)
Functional Keywords	egfr, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38072.50
Authors	Zhu, S.J. (deposition date: 2021-10-22, release date: 2022-06-08, Last modification date: 2023-11-29)
Primary citation	Chen, H.,Lai, M.,Zhang, T.,Chen, Y.,Tong, L.,Zhu, S.,Zhou, Y.,Ren, X.,Ding, J.,Xie, H.,Lu, X.,Ding, K. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J.Med.Chem., 65:6840-6858, 2022 Cited by PubMed: 35446588 DOI: 10.1021/acs.jmedchem.2c00168 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation