2GTX
| Structural Basis of Catalysis by Mononuclear Methionine Aminopeptidase | Descriptor: | (1-AMINO-PENTYL)-PHOSPHONIC ACID, MANGANESE (II) ION, Methionine aminopeptidase, ... | Authors: | Ye, Q.Z. | Deposit date: | 2006-04-28 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of catalysis by monometalated methionine aminopeptidase. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GU4
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2GU5
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2GU7
| E. coli methionine aminopeptidase unliganded, 1:0.5 | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase, SODIUM ION | Authors: | Ye, Q.Z. | Deposit date: | 2006-04-28 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of catalysis by monometalated methionine aminopeptidase. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GU6
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3D27
| E. coli methionine aminopeptidase with Fe inhibitor W29 | Descriptor: | 4-(3-ethylthiophen-2-yl)benzene-1,2-diol, MANGANESE (II) ION, Methionine aminopeptidase | Authors: | Ye, Q.Z, Chai, S, He, H.Z. | Deposit date: | 2008-05-07 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity. J.Med.Chem., 51, 2008
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4JUQ
| Pseudomonas aeruginosa MetAP T2N mutant, in Mn form | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2013-03-25 | Release date: | 2014-04-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Methionine excision captured by the structures of a methionine aminopeptidase To be published
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3IU7
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3IU9
| M. tuberculosis methionine aminopeptidase with Ni inhibitor T07 | Descriptor: | 5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine, CHLORIDE ION, Methionine aminopeptidase, ... | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2009-08-30 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase J.Med.Chem., 53, 2010
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3IU8
| M. tuberculosis methionine aminopeptidase with Ni inhibitor T03 | Descriptor: | 3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole, CHLORIDE ION, Methionine aminopeptidase, ... | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2009-08-30 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase J.Med.Chem., 53, 2010
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2BB7
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3PKE
| M. tuberculosis MetAP with bengamide analog Y10, in Ni form | Descriptor: | (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, CHLORIDE ION, Methionine aminopeptidase, ... | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2010-11-11 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. Chemmedchem, 6, 2011
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3PKB
| M. tuberculosis MetAP with bengamide analog Y16, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2010-11-11 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. Chemmedchem, 6, 2011
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3PKD
| M. tuberculosis MetAP with bengamide analog Y10, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2010-11-11 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. Chemmedchem, 6, 2011
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3PKC
| M. tuberculosis MetAP with bengamide analog Y08, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2010-11-11 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. Chemmedchem, 6, 2011
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3PKA
| M. tuberculosis MetAP with bengamide analog Y02, in Mn form | Descriptor: | (2R,3R,4S,5R,6E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[2-(2,4,6-trimethylphenoxy)ethyl]non-6-enamide, CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2010-11-11 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. Chemmedchem, 6, 2011
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4FLL
| Human MetAP1 with bengamide analog YZ6, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ... | Authors: | Ye, Q.Z, Xu, W. | Deposit date: | 2012-06-14 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55, 2012
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4FLI
| Human MetAP1 with bengamide analog Y16, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ... | Authors: | Ye, Q.Z, Xu, W. | Deposit date: | 2012-06-14 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55, 2012
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4FLJ
| Human MetAP1 with bengamide analog Y08, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ... | Authors: | Ye, Q.Z, Xu, W. | Deposit date: | 2012-06-14 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55, 2012
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4FO7
| Pseudomonas aeruginosa MetAP, in Mn form | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2012-06-20 | Release date: | 2013-07-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Methionine excision captured by the structures of a
methionine aminopeptidase To be published
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4FLK
| Human MetAP1 with bengamide analog Y10, in Mn form | Descriptor: | (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ... | Authors: | Ye, Q.Z, Xu, W. | Deposit date: | 2012-06-14 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55, 2012
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4FO8
| Pseudomonas aeruginosa MetAP with Met, in Mn form | Descriptor: | MANGANESE (II) ION, METHIONINE, Methionine aminopeptidase | Authors: | Ye, Q.Z, Lu, J.P. | Deposit date: | 2012-06-20 | Release date: | 2013-07-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Methionine excision captured by the structures of a
methionine aminopeptidase To be published
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1B8Y
| X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXED WITH NON-PEPTIDE INHIBITORS: IMPLICATIONS FOR INHIBITOR SELECTIVITY | Descriptor: | CALCIUM ION, PROTEIN (STROMELYSIN-1), SULFATE ION, ... | Authors: | Pavlovsky, A.G, Williams, M.G, Ye, Q.-Z, Ortwine, D.F, Purchase II, C.F, White, A.D, Dhanaraj, V, Roth, B.D, Johnson, L.L, Hupe, D, Humblet, C, Blundell, T.L. | Deposit date: | 1999-02-03 | Release date: | 1999-08-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci., 8, 1999
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1CAQ
| X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY | Descriptor: | 3-(1H-INDOL-3-YL)-2-[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-PROPIONIC ACID, CALCIUM ION, PROTEIN (STROMELYSIN-1), ... | Authors: | Pavlovsky, A.G, Williams, M.G, Ye, Q.-Z, Ortwine, D.F, Purchase II, C.F, White, A.D, Dhanaraj, V, Roth, B.D, Johnson, L.L, Hupe, D, Humblet, C, Blundell, T.L. | Deposit date: | 1999-02-23 | Release date: | 1999-07-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci., 8, 1999
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1UMS
| STROMELYSIN-1 CATALYTIC DOMAIN WITH HYDROPHOBIC INHIBITOR BOUND, PH 7.0, 32OC, 20 MM CACL2, 15% ACETONITRILE; NMR ENSEMBLE OF 20 STRUCTURES | Descriptor: | CALCIUM ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-L-leucyl-L-phenylalaninamide, STROMELYSIN-1, ... | Authors: | Van Doren, S.R, Kurochkin, A.V, Hu, W, Zuiderweg, E.R.P. | Deposit date: | 1995-10-31 | Release date: | 1996-03-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor. Protein Sci., 4, 1995
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