3PKE

M. tuberculosis MetAP with bengamide analog Y10, in Ni form

Summary for 3PKE

• Entry DOI: 10.2210/pdb3pke/pdb
• Related: 3IU7 3IU8 3IU9 3PKA 3PKB 3PKC 3PKD
• Descriptor: Methionine aminopeptidase, (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, NICKEL (II) ION, ... (6 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 31548.28

Authors

Ye, Q.Z.,Lu, J.P. (deposition date: 2010-11-11, release date: 2011-04-20, Last modification date: 2024-02-21)

• Primary citation: Lu, J.P.,Yuan, X.H.,Yuan, H.,Wang, W.L.,Wan, B.,Franzblau, S.G.,Ye, Q.Z.; Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.; Chemmedchem, 6:1041-1048, 2011; PubMed: 21465667; DOI: 10.1002/cmdc.201100003

Experimental method

X-RAY DIFFRACTION (1.6 Å)