3D27

E. coli methionine aminopeptidase with Fe inhibitor W29

Summary for 3D27

• Entry DOI: 10.2210/pdb3d27/pdb
• Related: 1XNZ
• Descriptor: Methionine aminopeptidase, MANGANESE (II) ION, 4-(3-ethylthiophen-2-yl)benzene-1,2-diol, ... (4 entities in total)
• Functional Keywords: dinuclear, manganese, iron, hydrolase, peptidase, enzyme-inhibitor complex, metalloenzyme, aminopeptidase, cobalt, metal-binding, protease
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 29385.58

Authors

Ye, Q.Z.,Chai, S.,He, H.Z. (deposition date: 2008-05-07, release date: 2008-08-19, Last modification date: 2024-02-21)

• Primary citation: Wang, W.L.,Chai, S.C.,Huang, M.,He, H.Z.,Hurley, T.D.,Ye, Q.Z.; Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.; J.Med.Chem., 51:6110-6120, 2008; PubMed: 18785729; DOI: 10.1021/jm8005788

Experimental method

X-RAY DIFFRACTION (2.2 Å)