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4FLI

Human MetAP1 with bengamide analog Y16, in Mn form

Summary for 4FLI
Entry DOI10.2210/pdb4fli/pdb
Related3PKA 3PKB 3PKC 3PKD 3PKE 4FLJ 4FLK 4FLL
DescriptorMethionine aminopeptidase 1, MANGANESE (II) ION, (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, ... (5 entities in total)
Functional Keywordsenzyme-inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P53582
Total number of polymer chains1
Total formula weight37296.12
Authors
Ye, Q.Z.,Xu, W. (deposition date: 2012-06-14, release date: 2012-09-19, Last modification date: 2024-02-28)
Primary citationXu, W.,Lu, J.P.,Ye, Q.Z.
Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J.Med.Chem., 55:8021-8027, 2012
Cited by
PubMed: 22913487
DOI: 10.1021/jm3008695
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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