4FLJ

Human MetAP1 with bengamide analog Y08, in Mn form

Summary for 4FLJ

• Entry DOI: 10.2210/pdb4flj/pdb
• Related: 3PKA 3PKB 3PKC 3PKD 3PKE 4FLI 4FLK 4FLL
• Descriptor: Methionine aminopeptidase 1, MANGANESE (II) ION, (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, ... (5 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P53582
• Total number of polymer chains: 1
• Total formula weight: 37404.30

Authors

Ye, Q.Z.,Xu, W. (deposition date: 2012-06-14, release date: 2012-09-19, Last modification date: 2024-02-28)

• Primary citation: Xu, W.,Lu, J.P.,Ye, Q.Z.; Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.; J.Med.Chem., 55:8021-8027, 2012; PubMed: 22913487; DOI: 10.1021/jm3008695

Experimental method

X-RAY DIFFRACTION (1.74 Å)