8ITY
| human RNA polymerase III pre-initiation complex closed DNA 1 | 分子名称: | DNA (82-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | 登録日 | 2023-03-23 | 公開日 | 2023-06-07 | 最終更新日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Cell Res., 33, 2023
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8HIT
| Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 | 分子名称: | Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL | 著者 | Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J. | 登録日 | 2022-11-21 | 公開日 | 2023-02-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer. Mabs, 15, 2023
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7XPI
| Structure of a oxidoreductase | 分子名称: | Apoptosis inducing factor mitochondria associated 2, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Lv, Y, Sun, Q, Wang, Q, Zhu, D. | 登録日 | 2022-05-04 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun, 14, 2023
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7CZB
| The cryo-EM structure of the ERAD retrotranslocation channel formed by human Derlin-1 | 分子名称: | Derlin-1 | 著者 | Rao, B, Li, S, Yao, D, Wang, Q, Xia, Y, Jia, Y, Shen, Y, Cao, Y. | 登録日 | 2020-09-07 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1. Sci Adv, 7, 2021
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7FIF
| Cryo-EM structure of the hedgehog release protein Disp from water bear (Hypsibius dujardini) | 分子名称: | Protein dispatched-like protein 1 | 著者 | Luo, Y, Wan, G, Wang, Q, Zhao, Y, Cong, Y, Li, D. | 登録日 | 2021-07-31 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release. Front Mol Biosci, 8, 2021
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7VZF
| Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | 登録日 | 2021-11-16 | 公開日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun, 13, 2022
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5X58
| Prefusion structure of SARS-CoV spike glycoprotein, conformation 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | 登録日 | 2017-02-15 | 公開日 | 2017-05-03 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun, 8, 2017
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5X5B
| Prefusion structure of SARS-CoV spike glycoprotein, conformation 2 | 分子名称: | Spike glycoprotein | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | 登録日 | 2017-02-15 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun, 8, 2017
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5X59
| Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | 登録日 | 2017-02-15 | 公開日 | 2017-05-03 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun, 8, 2017
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5X5C
| Prefusion structure of MERS-CoV spike glycoprotein, conformation 1 | 分子名称: | S protein | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | 登録日 | 2017-02-15 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-24 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun, 8, 2017
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5X5F
| Prefusion structure of MERS-CoV spike glycoprotein, conformation 2 | 分子名称: | S protein | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | 登録日 | 2017-02-15 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-24 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun, 8, 2017
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7XK2
| Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-19 | 公開日 | 2023-02-22 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7ZLY
| Crystal structure of human GPCR Niacin receptor (HCA2) expressed from Spodoptera frugiperda | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, OLEIC ACID | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, FiBerto, J.F, Wu, L.J, Tong, J.H, Han, G.W, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-17 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7ZL9
| Crystal structure of human GPCR Niacin receptor (HCA2) | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, ... | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, FiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-14 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7Y8R
| The nucleosome-bound human PBAF complex | 分子名称: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | 著者 | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | 登録日 | 2022-06-24 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
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7Y53
| The cryo-EM structure of human ERAD retro-translocation complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | 著者 | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | 登録日 | 2022-06-16 | 公開日 | 2023-10-18 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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7Y4W
| The cryo-EM structure of human ERAD retro-translocation complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | 著者 | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | 登録日 | 2022-06-16 | 公開日 | 2023-10-18 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | 主引用文献 | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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7Y59
| The cryo-EM structure of human ERAD retro-translocation complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Derlin-1, ... | 著者 | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | 登録日 | 2022-06-16 | 公開日 | 2023-10-18 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.51 Å) | 主引用文献 | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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6D88
| Tubulin-RB3_SLD-TTL in complex with compound 13f | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2018-04-26 | 公開日 | 2018-09-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.853 Å) | 主引用文献 | Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities. J. Med. Chem., 61, 2018
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4XI2
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6IEC
| Structure of RVFV Gn and human monoclonal antibody R17 | 分子名称: | NSmGnGc, R17 H chain, R17 L chain | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | 登録日 | 2018-09-13 | 公開日 | 2019-04-10 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nat Microbiol, 4, 2019
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6IEA
| Structure of RVFV Gn and human monoclonal antibody R13 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NSmGnGc, ... | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | 登録日 | 2018-09-13 | 公開日 | 2019-04-10 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nat Microbiol, 4, 2019
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6IEK
| Structure of RVFV Gn and human monoclonal antibody R12 | 分子名称: | Heavy chain of Fab R12, Light chain of Fab R12, NSmGnGc | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | 登録日 | 2018-09-14 | 公開日 | 2019-04-10 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nat Microbiol, 4, 2019
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6IEB
| Structure of RVFV Gn and human monoclonal antibody R15 | 分子名称: | NSmGnGc, R15 H chain, R15 L chain | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | 登録日 | 2018-09-13 | 公開日 | 2019-04-10 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (2.409 Å) | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nat Microbiol, 4, 2019
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5GZR
| Zika virus E protein complexed with a neutralizing antibody Z23-Fab | 分子名称: | Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... | 著者 | Gao, G.G, Shi, Y, Peng, R, Liu, S. | 登録日 | 2016-10-01 | 公開日 | 2016-11-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (9.4 Å) | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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