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Structure of citryl-CoA lyase from Hydrogenobacter thermophilus
Descriptor:	COENZYME A, Citryl-CoA lyase, SULFATE ION
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

6HXK

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate
Descriptor:	1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ...
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

6HXQ

Structure of citryl-CoA synthetase from Hydrogenobacter thermophilus
Descriptor:	CITRATE ANION, COENZYME A, Citryl-CoA synthetase large subunit, ...
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.91 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

6HXM

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221
Descriptor:	ATP-citrate synthase, CITRATE ANION, COENZYME A
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

6HXH

Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ...
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

6HXI

Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A
Descriptor:	ACETATE ION, CITRATE ANION, COENZYME A, ...
Authors:	Verstraete, K, Verschueren, K.
Deposit date:	2018-10-17
Release date:	2019-04-10
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019

1EDD

CRYSTALLOGRAPHIC AND FLUORESCENCE STUDIES OF THE INTERACTION OF HALOALKANE DEHALOGENASE WITH HALIDE IONS: STUDIES WITH HALIDE COMPOUNDS REVEAL A HALIDE BINDING SITE IN THE ACTIVE SITE
Descriptor:	CHLORIDE ION, HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry, 32, 1993

1EDE

REFINED X-RAY STRUCTURES OF HALOALKANE DEHALOGENASE AT PH 6.2 AND PH 8.2 AND IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:	HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Refined X-ray structures of haloalkane dehalogenase at pH 6.2 and pH 8.2 and implications for the reaction mechanism. J.Mol.Biol., 232, 1993

1EDB

CRYSTALLOGRAPHIC AND FLUORESCENCE STUDIES OF THE INTERACTION OF HALOALKANE DEHALOGENASE WITH HALIDE IONS: STUDIES WITH HALIDE COMPOUNDS REVEAL A HALIDE BINDING SITE IN THE ACTIVE SITE
Descriptor:	CHLORIDE ION, HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry, 32, 1993

2HAD

CRYSTAL STRUCTURE OF HALOALKANE DEHALOGENASE: AN ENZYME TO DETOXIFY HALOGENATED ALKANES
Descriptor:	HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Franken, S.M, Dijkstra, B.W.
Deposit date:	1992-08-07
Release date:	1993-01-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes. EMBO J., 10, 1991

2DHE

CRYSTALLOGRAPHIC ANALYSIS OF THE CATALYTIC MECHANISM OF HALOALKANE DEHALOGENASE
Descriptor:	CHLORIDE ION, HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-06-24
Release date:	1994-08-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature, 363, 1993

2DHD

CRYSTALLOGRAPHIC ANALYSIS OF THE CATALYTIC MECHANISM OF HALOALKANE DEHALOGENASE
Descriptor:	CHLORIDE ION, HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-09-08
Release date:	1994-07-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature, 363, 1993

2DHC

CRYSTALLOGRAPHIC ANALYSIS OF THE CATALYTIC MECHANISM OF HALOALKANE DEHALOGENASE
Descriptor:	1,2-DICHLOROETHANE, HALOALKANE DEHALOGENASE
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-09-08
Release date:	1994-07-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature, 363, 1993

2EDC

CRYSTALLOGRAPHIC AND FLUORESCENCE STUDIES OF THE INTERACTION OF HALOALKANE DEHALOGENASE WITH HALIDE IONS: STUDIES WITH HALIDE COMPOUNDS REVEAL A HALIDE BINDING SITE IN THE ACTIVE SITE
Descriptor:	HALOALKANE DEHALOGENASE, IODIDE ION
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-08-31
Release date:	1994-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry, 32, 1993

2EDA

CRYSTALLOGRAPHIC AND FLUORESCENCE STUDIES OF THE INTERACTION OF HALOALKANE DEHALOGENASE WITH HALIDE IONS: STUDIES WITH HALIDE COMPOUNDS REVEAL A HALIDE BINDING SITE IN THE ACTIVE SITE
Descriptor:	HALOALKANE DEHALOGENASE, IODIDE ION
Authors:	Verschueren, K.H.G, Dijkstra, B.W.
Deposit date:	1993-08-30
Release date:	1993-10-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry, 32, 1993

7S5B

Unbound State of a De novo designed Protein Binder to the Human Interleukin-7 Receptor
Descriptor:	Miniprotein Binder
Authors:	Walsh, S.T.R, Cao, L, Baker, D.
Deposit date:	2021-09-10
Release date:	2022-05-11
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7RDH

Crystal structure of the de novo designed binding protein H3mb in complex with the 1968 influenza A virus hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, De novo designed protein H3mb, ...
Authors:	Kadam, R.U, Wilson, I.A.
Deposit date:	2021-07-09
Release date:	2022-05-04
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7Z3Q

Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
Descriptor:	Leptin, Leptin receptor
Authors:	Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N.
Deposit date:	2022-03-02
Release date:	2023-03-22
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (3.617 Å)
Cite:	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

7Z3R

Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution.
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
Authors:	Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A.
Deposit date:	2022-03-02
Release date:	2023-03-22
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.951 Å)
Cite:	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

7Z3P

Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.
Descriptor:	CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ...
Authors:	Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K.
Deposit date:	2022-03-02
Release date:	2023-03-22
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.943 Å)
Cite:	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

7N1J

Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder
Descriptor:	Binder, Fibroblast growth factor receptor 4
Authors:	Park, J.S, Lee, S.
Deposit date:	2021-05-27
Release date:	2022-04-06
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.99 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7N1K

Crystal structure of a de novo-designed mini-protein targeting FGFR
Descriptor:	Binder
Authors:	Park, J.S, Lee, S.
Deposit date:	2021-05-27
Release date:	2022-04-06
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (3.01 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7N3T

TrkA ECD complex with designed miniprotein ligand
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Jude, K.M, Cao, L, Garcia, K.C.
Deposit date:	2021-06-01
Release date:	2022-04-20
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.84 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

8AVE

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
Descriptor:	Leptin, Leptin receptor
Authors:	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:	2022-08-26
Release date:	2023-04-05
Last modified:	2023-04-26
Method:	ELECTRON MICROSCOPY (5.62 Å)
Cite:	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

8AVO

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).
Descriptor:	Leptin, Leptin receptor
Authors:	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:	2022-08-26
Release date:	2023-04-05
Last modified:	2023-04-26
Method:	ELECTRON MICROSCOPY (6.84 Å)
Cite:	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

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