8I85
| Crystal structure of Cph001-D189N in complex with ATP | Descriptor: | ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-03 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I84
| Crystal structure of Cph001-D189N in complex with CMN IIB | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, KBE-DPP-UAL-MYN-DPP-ALA, ... | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-03 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I8G
| Crystal structure of Cph001-D189N in complex with CMN IIA and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, KBE-DPP-UAL-MYN-DPP-SER, Viomycin kinase | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-04 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I86
| Crystal structure of Cph001-D189N in complex with GTP | Descriptor: | DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-TRIPHOSPHATE, Viomycin kinase | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-03 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I8H
| Crystal structure of Cph001-D189N in complex with VIO and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, KBE-DPP-SER-SER-UAL-5OH, ... | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-04 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I80
| Crystal structure of Cph001-D189N | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, Viomycin kinase | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J. | Deposit date: | 2023-02-02 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I89
| Crystal structure of Cph001-D189N in complex with VIO | Descriptor: | DI(HYDROXYETHYL)ETHER, KBE-DPP-SER-SER-UAL-5OH, Viomycin kinase | Authors: | Chang, C.Y, Toh, S.I, Elaine K, J, Hsiao, P.Y. | Deposit date: | 2023-02-03 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. Commun Biol, 6, 2023
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8I82
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8IF7
| Crystal structure of CmnB | Descriptor: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CmnB | Authors: | Chang, C.Y, Toh, S.I, Lo, C.L. | Deposit date: | 2023-02-17 | Release date: | 2023-07-26 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of CmnB involved in the biosynthesis of the nonproteinogenic amino acid L-2,3-diaminopropionic acid. Acta Crystallogr.,Sect.F, 79, 2023
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7F0C
| Crystal structure of capreomycin phosphotransferase in complex with CMN IIA | Descriptor: | Capreomycin phosphotransferase, DPP-SER-DPP-UAL-MYN-KBE | Authors: | Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. | Deposit date: | 2021-06-03 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
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7F0B
| Crystal structure of capreomycin phosphotransferase in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Capreomycin phosphotransferase | Authors: | Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. | Deposit date: | 2021-06-03 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
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7F0A
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7F0F
| Crystal structure of capreomycin phosphotransferase in complex with CMN IIB | Descriptor: | Capreomycin phosphotransferase, DPP-ALA-DPP-UAL-MYN-KBE | Authors: | Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. | Deposit date: | 2021-06-03 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
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7YW9
| Crystal structure of the triple mutant CmnC-L136Q,S138G,D249Y in complex with alpha-KG | Descriptor: | ACETATE ION, CmnC, D-ARGININE, ... | Authors: | Huang, S.J, Hsiao, Y.H, Lin, E.C, Hsiao, P.Y, Chang, C.Y. | Deposit date: | 2022-08-22 | Release date: | 2023-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer. Front Chem, 10, 2022
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8HCD
| Crystal structure of mTREX1-DNA product complex (dNMP) | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, COBALT (II) ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCH
| Crystal structure of mTREX1-Uridine complex | Descriptor: | MAGNESIUM ION, Three-prime repair exonuclease 1, URIDINE | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCE
| Crystal structure of mTREX1-CMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCC
| Crystal structure of mTREX1-RNA product complex (AMP) | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCF
| Crystal structure of mTREX1-UMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, Three-prime repair exonuclease 1, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCG
| Crystal structure of mTREX1-dAMP complex | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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6A46
| Structure of TREX2 in complex with a nucleotide (dCMP) | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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6A4B
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6A47
| Structure of TREX2 in complex with a Y structured dsDNA | Descriptor: | DNA (5'-D(P*CP*CP*AP*GP*GP*CP*CP*CP*TP*CP*TP*AP*GP*GP*GP*CP*CP*TP*T)-3'), MAGNESIUM ION, SODIUM ION, ... | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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6A45
| Structure of mouse TREX2 | Descriptor: | PHOSPHATE ION, Three prime repair exonuclease 2 | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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7VGN
| Crystal structure of CmnC | Descriptor: | 2-OXOGLUTARIC ACID, ACETATE ION, CmnC, ... | Authors: | Huang, S.J, Hsiao, Y.H, Lin, E.C, Lee, Y.C, Zheng, Y.Z, Chang, C.Y. | Deposit date: | 2021-09-17 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer. Front Chem, 10, 2022
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