4O69
| Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion | 分子名称: | Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O6A
| Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA | 分子名称: | Cyclic GMP-AMP synthase, DNA1, DNA2, ... | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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3Q0T
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8IBY
| Structure of R2 with 5'ORF | 分子名称: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | 登録日 | 2023-02-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
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8IBX
| Structure of R2 with 3'UTR and DNA in unwinding state | 分子名称: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | 登録日 | 2023-02-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
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8IBW
| Structure of R2 with 3'UTR and DNA in binding state | 分子名称: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | 登録日 | 2023-02-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
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8IBZ
| Structure of R2 with 5'ORF and 3'UTR | 分子名称: | 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | 登録日 | 2023-02-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
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3SW9
| GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide | 分子名称: | DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, SINEFUNGIN, ... | 著者 | Chang, Y, Horton, J.R, Zhang, X, Cheng, X. | 登録日 | 2011-07-13 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 2011
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3SWW
| Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one, ... | 著者 | Klei, H.E. | 登録日 | 2011-07-14 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett., 21, 2011
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3SVM
| Human MPP8 - human DNMT3AK47me2 peptide | 分子名称: | DNA (cytosine-5)-methyltransferase 3A, M-phase phosphoprotein 8 | 著者 | Chang, Y, Horton, J.R, Zhang, X, Cheng, X. | 登録日 | 2011-07-12 | 公開日 | 2011-11-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 2011
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3SWC
| GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide | 分子名称: | DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Chang, Y, Horton, J.R, Zhang, X, Cheng, X. | 登録日 | 2011-07-13 | 公開日 | 2011-11-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.332 Å) | 主引用文献 | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 2011
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3SX4
| Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one, ... | 著者 | Klei, H.E. | 登録日 | 2011-07-14 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett., 21, 2011
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7WL4
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50 | 分子名称: | Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide | 著者 | Zhang, C, Wang, C, Li, W, Zhang, Y, Xu, Y, Sun, L. | 登録日 | 2022-01-12 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors. Bioorg.Chem., 127, 2022
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4IMB
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4IYG
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4JH0
| Crystal structure of dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) (DPP-IV-WT) complex with bms-767778 AKA 2-(3-(aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6h-pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide | 分子名称: | 2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-dimethylacetamide, Dipeptidyl peptidase 4 | 著者 | Klei, H.E. | 登録日 | 2013-03-04 | 公開日 | 2013-09-04 | 最終更新日 | 2013-10-09 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). J.Med.Chem., 56, 2013
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4KSY
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4LKO
| Crystal structure of human DPP-IV in complex with BMS-744891 | 分子名称: | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, Dipeptidyl peptidase 4 | 著者 | Klei, H.E. | 登録日 | 2013-07-08 | 公開日 | 2013-09-04 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). J.Med.Chem., 56, 2013
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7DV5
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7E1A
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7C4D
| Marine microorganism esterase | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Putative esterase, ... | 著者 | Zhu, C.H, Wu, Y.K, Isupov, M.N. | 登録日 | 2020-05-16 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design. J.Agric.Food Chem., 69, 2021
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7WWH
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5Z6Q
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6AE8
| Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement | 分子名称: | BICINE, Histone H2A.Z-specific chaperone CHZ1, Histone H2B.1,Histone H2A.Z | 著者 | Wang, Y.Y, Shan, S, Zhou, Z. | 登録日 | 2018-08-03 | 公開日 | 2019-04-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement. Plos Biol., 17, 2019
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7V2A
| SARS-CoV-2 Spike trimer in complex with XG014 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, The heavy chain of XG014, ... | 著者 | Wang, K, Wang, X, Pan, L. | 登録日 | 2021-08-07 | 公開日 | 2021-10-20 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell, 13, 2022
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