1YSL
 
 | | Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand. | | 分子名称: | ACETOACETIC ACID, COENZYME A, GLYCEROL, ... | | 著者 | Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. | | 登録日 | 2005-02-08 | | 公開日 | 2005-11-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
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2HDB
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1JM6
 | | Pyruvate dehydrogenase kinase, isozyme 2, containing ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pyruvate dehydrogenase kinase, ... | | 著者 | Steussy, C.N, Popov, K.M, Bowker-Kinley, M.M, Sloan, R.B, Harris, R.A, Hamilton, J.A. | | 登録日 | 2001-07-17 | | 公開日 | 2001-10-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase.
J.Biol.Chem., 276, 2001
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1X9E
 | | Crystal structure of HMG-CoA synthase from Enterococcus faecalis | | 分子名称: | HMG-CoA synthase, SULFATE ION | | 著者 | Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. | | 登録日 | 2004-08-20 | | 公開日 | 2005-11-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
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4I56
 | | HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa | | 分子名称: | (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | | 著者 | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Crichelow, C.J, Rodwell, V.W, Wrensford, L.V, Min, J, Burgner II, J.W. | | 登録日 | 2012-11-28 | | 公開日 | 2013-07-17 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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4I64
 | | 3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure | | 分子名称: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | | 著者 | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | | 登録日 | 2012-11-29 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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4I6A
 | | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA | | 分子名称: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | | 著者 | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | | 登録日 | 2012-11-29 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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4I6W
 | | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate | | 分子名称: | (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | | 著者 | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | | 登録日 | 2012-11-30 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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4I6Y
 | | 3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate | | 分子名称: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | | 著者 | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | | 登録日 | 2012-11-30 | | 公開日 | 2013-07-17 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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4I4B
 | | HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA | | 分子名称: | (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ... | | 著者 | Stauffacher, C.V, Steussy, C.N, Critchelow, C.J, Schmidt, T, Min, J, Wrensford, L.V, Burgner, J.W, Rodwell, V.W. | | 登録日 | 2012-11-27 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
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8GDN
 | | Structure of PmHMGR bound to mevalonate, CoA and NAD. | | 分子名称: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | | 著者 | Purohit, V, Steussy, C.N, Stauffacher, C.V. | | 登録日 | 2023-03-06 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
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5JNP
 | | Crystal structure of a rice (Oryza Sativa) cellulose synthase plant conserved region (P-CR) | | 分子名称: | CITRATE ANION, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Rushton, P.S, Olek, A.T, Makowski, L, Badger, J, Steussy, C.N, Carpita, N.C, Stauffacher, C.V. | | 登録日 | 2016-04-30 | | 公開日 | 2016-12-28 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | | 主引用文献 | Rice Cellulose SynthaseA8 Plant-Conserved Region Is a Coiled-Coil at the Catalytic Core Entrance.
Plant Physiol., 173, 2017
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2PNR
 | | Crystal Structure of the asymmetric Pdk3-l2 Complex | | 分子名称: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 | | 著者 | Vassylyev, D.G, Steussy, C.N, Devedjiev, Y. | | 登録日 | 2007-04-25 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of an Asymmetric complex of Pyruvate Dehydrogenase
Kinase 3 with Lipoyl domain 2 and its Biological Implications
J.Mol.Biol., 370, 2007
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8VLQ
 | | Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9 | | 分子名称: | (R)-MEVALONATE, (R)-mevaldehyde, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Purohit, V, Steussy, C.N, Stauffacher, C.V. | | 登録日 | 2024-01-12 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
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8SZ6
 | | PmHMGR bound to mevaldehyde and CoA | | 分子名称: | (3R)-3,5,5-trihydroxy-3-methylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Mevaldyl-Coenzyme A, ... | | 著者 | Purohit, V, Stauffacher, C.V, Steussy, C.N. | | 登録日 | 2023-05-27 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
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1R7I
 | | HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. | | 分子名称: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION | | 著者 | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | | 登録日 | 2003-10-21 | | 公開日 | 2003-11-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
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1R31
 | | HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA | | 分子名称: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | | 著者 | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | | 登録日 | 2003-09-30 | | 公開日 | 2003-10-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
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7M1Z
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7M3H
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7M66
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5V2L
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5V2M
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6E2S
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6E2T
 | | MDDEF in complex with MVAPP | | 分子名称: | (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, Mevalonate diphosphate decarboxylase | | 著者 | Stauffacher, C.V, Chen, C.-L. | | 登録日 | 2018-07-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.692 Å) | | 主引用文献 | Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase.
Nat Commun, 11, 2020
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6E2U
 | | MDDEF in complex with MVAPP, AMPPCP and Magnesium | | 分子名称: | (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, MAGNESIUM ION, Mevalonate diphosphate decarboxylase, ... | | 著者 | Stauffacher, C.V, Chen, C.-L. | | 登録日 | 2018-07-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase.
Nat Commun, 11, 2020
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