6KX4
 
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6DTL
 | | Mitogen-activated protein kinase 6 | | 分子名称: | Mitogen-activated protein kinase 6 | | 著者 | Ruble, J. | | 登録日 | 2018-06-17 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | | 主引用文献 | Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP kinases to SPEECHLESS.
Nat.Plants, 5, 2019
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6FBV
 | | Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Das, K, Lin, W, Ebright, E. | | 登録日 | 2017-12-19 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
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6K7D
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6K7E
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6A1C
 | | Crystal structure of the CK2a1-go289 complex | | 分子名称: | 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, Casein kinase II subunit alpha, ... | | 著者 | Kinoshita, T, Tsuyuguchi, M. | | 登録日 | 2018-06-07 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
Sci Adv, 5, 2019
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7D0N
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7DLI
 | | Crystal structure of mouse CRY1 in complex with KL001 compound | | 分子名称: | 1,2-ETHANEDIOL, Cryptochrome-1, N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide | | 著者 | Miller, S.A, Aikawa, Y, Hirota, T. | | 登録日 | 2020-11-27 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7D0M
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7EJ9
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6ASG
 | | Crystal structure of Thermus thermophilus RNA polymerase core enzyme | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | | 登録日 | 2017-08-24 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
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4NJE
 | | Crystal structure of Pyrococcus furiosus L-asparaginase with ligand | | 分子名称: | ASPARTIC ACID, L-asparaginase | | 著者 | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | | 登録日 | 2013-11-09 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr.,Sect.D, 70, 2014
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4Q0M
 | | Crystal structure of Pyrococcus furiosus L-asparaginase | | 分子名称: | (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, GLYCEROL, L-asparaginase, ... | | 著者 | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | | 登録日 | 2014-04-02 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | | 主引用文献 | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr.,Sect.D, 70, 2014
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4RA9
 | | Crystal Structure of Conjoint Pyrococcus Furiosus L-asparaginase with Citrate | | 分子名称: | CITRATE ANION, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | | 登録日 | 2014-09-09 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr.,Sect.D, 70, 2014
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4RA6
 | | Crystal structure of linker less Pyrococcus furiosus L-asparaginase | | 分子名称: | GLYCEROL, L-asparaginase | | 著者 | Sharma, P, Tomar, R, Ashish, Kundu, B. | | 登録日 | 2014-09-09 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr.,Sect.D, 70, 2014
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6OF7
 | | Crystal structure of the CRY1-PER2 complex | | 分子名称: | Cryptochrome-1, Period circadian protein homolog 2 | | 著者 | Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L. | | 登録日 | 2019-03-28 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.
Elife, 9, 2020
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6X87
 | | CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. | | 分子名称: | 3D11 Fab heavy chain, 3D11 Fab kappa chain, Circumsporozoite protein | | 著者 | Kucharska, I, Thai, E, Rubinstein, J, Julien, J.P. | | 登録日 | 2020-06-01 | | 公開日 | 2020-12-02 | | 最終更新日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11.
Elife, 9, 2020
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6X8S
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6X8Q
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6X8U
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6X8P
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8BIK
 | | Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455 | | 分子名称: | (3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-[[6-chloranyl-5-[4-[4-[[dimethyl(oxidanyl)-$l^{4}-sulfanyl]amino]phenyl]phenyl]-3~{H}-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]furan-3-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... | | 著者 | Schimpl, M, Mather, K.M, Boland, M.L, Rivers, E.L, Srivastava, A, Hemsley, P, Robinson, J, Wan, P.T, Hansen, J, Read, J.A, Trevaskis, J.L, Smith, D.M. | | 登録日 | 2022-11-02 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Direct AMPK Activator Reduces Liver Steatosis but Does Not Alter Fibrosis in a Mouse Model of Non-Alcoholic Steatohepatitis
To be published
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2H02
 | | Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | | 分子名称: | Protein tyrosine phosphatase, receptor type, B,, ... | | 著者 | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | | 登録日 | 2006-05-13 | | 公開日 | 2006-06-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorg.Med.Chem.Lett., 16, 2006
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2H04
 | | Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | | 分子名称: | Protein tyrosine phosphatase, receptor type, B,, ... | | 著者 | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | | 登録日 | 2006-05-13 | | 公開日 | 2006-06-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorg.Med.Chem.Lett., 16, 2006
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2H03
 | | Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | | 分子名称: | (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | | 登録日 | 2006-05-13 | | 公開日 | 2006-06-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorg.Med.Chem.Lett., 16, 2006
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