8HP3
| Crystal structure of meso-diaminopimelate dehydrogenase from Prevotella timonensis | Descriptor: | 1,2-ETHANEDIOL, Meso-diaminopimelate D-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tan, Y, Song, W. | Deposit date: | 2022-12-11 | Release date: | 2023-12-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Rational Design of Meso -Diaminopimelate Dehydrogenase with Enhanced Reductive Amination Activity for Efficient Production of d- p -Hydroxyphenylglycine. Appl.Environ.Microbiol., 89, 2023
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8HP0
| Crystal structure of meso-diaminopimelate dehydrogenase from Prevotella timonensis | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Meso-diaminopimelate D-dehydrogenase, SULFATE ION | Authors: | Tan, Y, Song, W. | Deposit date: | 2022-12-11 | Release date: | 2023-12-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Rational Design of Meso -Diaminopimelate Dehydrogenase with Enhanced Reductive Amination Activity for Efficient Production of d- p -Hydroxyphenylglycine. Appl.Environ.Microbiol., 89, 2023
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8HPI
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8HPG
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8I7H
| Meso-Diaminopimelate dehydrogenase | Descriptor: | 2,6-DIAMINOPIMELIC ACID, Meso-diaminopimelate D-dehydrogenase, SULFATE ION | Authors: | Wu, T.F, Song, W. | Deposit date: | 2023-01-31 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Analysis of the catalytic mechanism of meso-DAPDH and extension of D-aromatic amino acid substrate scope To Be Published
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7ETW
| Cryo-EM structure of Scap/Insig complex in the present of digitonin. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Digitonin, Insulin-induced gene 2 protein, ... | Authors: | Yan, R, Cao, P, Song, W, Li, Y, Wang, T, Qian, H, Yan, C, Yan, N. | Deposit date: | 2021-05-14 | Release date: | 2021-06-23 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for sterol sensing by Scap and Insig Cell Rep, 35, 2021
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8HPC
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8HP4
| CtPDC complex | Descriptor: | MAGNESIUM ION, Pyruvate decarboxylase, THIAMINE DIPHOSPHATE | Authors: | Xu, H.H, Song, W. | Deposit date: | 2022-12-11 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Protein engineering of pyruvate decarboxylase to remove the rate-limiting bottleneck in the cascade pathway of tyrosol synthesis To Be Published
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8HP2
| CtPDC | Descriptor: | Pyruvate decarboxylase | Authors: | Xu, H.H, Song, W. | Deposit date: | 2022-12-11 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Protein engineering of pyruvate decarboxylase to remove the rate-limiting bottleneck in the cascade pathway of tyrosol synthesis To Be Published
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7F18
| Crystal Structure of a mutant of acid phosphatase from Pseudomonas aeruginosa (Q57H/W58P/D135R) | Descriptor: | Acid phosphatase | Authors: | Xu, X, Hou, X.D, Song, W, Yin, D.J, Rao, Y.J, Liu, L.M. | Deposit date: | 2021-06-08 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Local Electric Field Modulated Reactivity of Pseudomonas aeruginosa Acid Phosphatase for Enhancing Phosphorylation of l-Ascorbic Acid Acs Catalysis, 11, 2021
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7F17
| Crystal Structure of acid phosphatase | Descriptor: | Acid phosphatase | Authors: | Xu, X, Hou, X.D, Song, W, Rao, Y.J, Liu, L.M, Wu, J. | Deposit date: | 2021-06-08 | Release date: | 2021-10-27 | Last modified: | 2022-05-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Local Electric Field Modulated Reactivity of Pseudomonas aeruginosa Acid Phosphatase for Enhancing Phosphorylation of l-Ascorbic Acid Acs Catalysis, 11, 2021
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6M49
| cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | Descriptor: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | Authors: | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | Deposit date: | 2020-03-06 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science, 371, 2021
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7CRC
| Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Avirulence protein ATR1, ... | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-08-13 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7CRB
| Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1 | Descriptor: | Avirulence protein ATR1, NAD+ hydrolase (NADase) | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-08-13 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7DFV
| Cryo-EM structure of plant NLR RPP1 tetramer core part | Descriptor: | NAD+ hydrolase (NADase) | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-11-10 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7VU8
| L7-Tir domain with bound ligand | Descriptor: | 2',3'- cyclic AMP, Flax rust resistance protein | Authors: | Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J. | Deposit date: | 2021-11-01 | Release date: | 2022-06-01 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. Cell, 185, 2022
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7X5L
| Tir-dsDNA complex, the initial binding state | Descriptor: | DNA (5'-D(*AP*TP*AP*AP*AP*TP*TP*A)-3'), DNA (5'-D(*TP*TP*AP*AP*TP*TP*AP*A)-3'), Flax rust resistance protein | Authors: | Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J. | Deposit date: | 2022-03-04 | Release date: | 2022-06-01 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. Cell, 185, 2022
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7X5K
| Tir-dsDNA complex, the initial binding state | Descriptor: | DNA (43-MER), Flax rust resistance protein | Authors: | Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J. | Deposit date: | 2022-03-04 | Release date: | 2022-06-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. Cell, 185, 2022
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7X5M
| Tir-dsDNA complex, the initial binding state | Descriptor: | 2',3'- cyclic AMP, DNA (5'-D(P*AP*TP*TP*AP*A)-3'), DNA (5'-D(P*AP*TP*TP*TP*A)-3'), ... | Authors: | Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J. | Deposit date: | 2022-03-05 | Release date: | 2022-06-01 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. Cell, 185, 2022
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7B0N
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3S41
| Glucokinase in complex with activator and glucose | Descriptor: | Glucokinase, N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide, SODIUM ION, ... | Authors: | Liu, S. | Deposit date: | 2011-05-18 | Release date: | 2011-09-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus MEDCHEMCOMM, 2, 2011
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3H0J
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3H0Q
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3H0S
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8IYQ
| Structure of CbCas9 bound to 20-nucleotide complementary DNA substrate | Descriptor: | NTS, TS, deadCbCas9, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-04-05 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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