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BU of 4gvj by Molmil

Tyk2 (JH1) in complex with adenosine di-phosphate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2
著者	Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S.
登録日	2012-08-30
公開日	2013-08-14
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.03 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013

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BU of 5wal by Molmil

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H, Magnuson, S.
登録日	2017-06-26
公開日	2017-09-06
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.45 Å)
主引用文献	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

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BU of 5wev by Molmil

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
著者	Ultsch, M.H, Magnuson, S.
登録日	2017-07-10
公開日	2017-09-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.854 Å)
主引用文献	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

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BU of 4gmy by Molmil

JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE
分子名称:	2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide, Tyrosine-protein kinase JAK2
著者	Murray, J.M, Shia, S.
登録日	2012-08-16
公開日	2013-06-19
最終更新日	2013-08-07
実験手法	X-RAY DIFFRACTION (2.403 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013

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BU of 4gfo by Molmil

TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE
分子名称:	1,2-ETHANEDIOL, 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide, GLYCEROL, ...
著者	Eigenbrot, C, Ultsch, M.
登録日	2012-08-03
公開日	2013-06-19
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013

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BU of 4gj3 by Molmil

Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
分子名称:	2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H.
登録日	2012-08-09
公開日	2013-05-29
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J.Med.Chem., 56, 2013

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BU of 4gj2 by Molmil

Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
分子名称:	2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H.
登録日	2012-08-09
公開日	2013-05-29
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J.Med.Chem., 56, 2013

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BU of 4gii by Molmil

Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide
分子名称:	2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H.
登録日	2012-08-08
公開日	2013-05-29
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J.Med.Chem., 56, 2013

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BU of 4gih by Molmil

Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE
分子名称:	2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H.
登録日	2012-08-08
公開日	2013-06-19
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013

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BU of 4gfm by Molmil

JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE
分子名称:	2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide, Tyrosine-protein kinase JAK2
著者	Eigenbrot, C, Ultsch, M.
登録日	2012-08-03
公開日	2013-06-19
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013

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