4GFO

TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE

Summary for 4GFO

Entry DOI	10.2210/pdb4gfo/pdb
Related	4GFM 4GIH 4GMY
Descriptor	Non-receptor tyrosine-protein kinase TYK2, SULFATE ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35693.52
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2012-08-03, release date: 2013-06-19, Last modification date: 2023-09-13)
Primary citation	Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S. Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67:175-187, 2013 Cited by PubMed: 23867602 DOI: 10.1016/j.ejmech.2013.03.070 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation