4GFO

TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Non-receptor tyrosine-protein kinase TYK2	polymer	302	35002.1	1	UniProt (P29597) Pfam (PF07714)	Homo sapiens (human)
2	B, C (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, E (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	F (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	G (A)	2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	non-polymer		283.1	1	Chemie (0X2)
6	H (A)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A: 884 - 1176 (UniProt: P29597)

PDB	External Database	Details
Met 882	-	expression tag
Gly 883	-	expression tag
Ser 1016	Ala 1016	conflict
Asn 1023	Asp 1023	engineered mutation
Arg 1177	-	expression tag
His 1178	-	expression tag
His 1179	-	expression tag
His 1180	-	expression tag
His 1181	-	expression tag
His 1182	-	expression tag
His 1183	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35002.1
Non-Polymers*	Number of molecules	6
	Total formula weight	691.5
All*	Total formula weight	35693.5

*Water molecules are not included.