1AD5
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2HCK
| SRC FAMILY KINASE HCK-QUERCETIN COMPLEX | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, CALCIUM ION, HEMATOPOETIC CELL KINASE HCK | 著者 | Sicheri, F, Moarefi, I, Kuriyan, J. | 登録日 | 1997-02-25 | 公開日 | 1997-08-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 1997
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1WFA
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1WFB
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1B0X
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4QLB
| Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin | 分子名称: | GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ... | 著者 | Zeqiraj, E, Judd, A, Sicheri, F. | 登録日 | 2014-06-11 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for the recruitment of glycogen synthase by glycogenin. Proc.Natl.Acad.Sci.USA, 111, 2014
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8E23
| Human DNA polymerase theta in complex with allosteric inhibitor | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | 登録日 | 2022-08-13 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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8E24
| Human DNA polymerase theta in complex with allosteric inhibitor | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | 登録日 | 2022-08-13 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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5KGF
| Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | 著者 | Wilson, M.D, Benlekbir, S, Sicheri, F, Rubinstein, J.L, Durocher, D. | 登録日 | 2016-06-13 | 公開日 | 2016-07-27 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (4.54 Å) | 主引用文献 | The structural basis of modified nucleosome recognition by 53BP1. Nature, 536, 2016
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7RMA
| Structure of the fourth UIM (Ubiquitin Interacting Motif) of ANKRD13D in complex with a high affinity UbV (Ubiquitin Variant) | 分子名称: | Ankyrin repeat domain-containing protein 13D, SODIUM ION, SULFATE ION, ... | 著者 | Singer, A.U, Manczyk, N, Veggiani, G, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-07-27 | 公開日 | 2022-05-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. Acs Chem.Biol., 17, 2022
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6ML1
| Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-09-26 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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6UBH
| Structure of the MM7 Erbin PDZ variant in complex with a high-affinity peptide | 分子名称: | Erbin, SODIUM ION, peptide | 著者 | Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S. | 登録日 | 2019-09-11 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain. J.Mol.Biol., 433, 2021
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6UUO
| Crystal structure of BRAF kinase domain bound to the PROTAC P4B | 分子名称: | N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | 著者 | Maisonneuve, P, Posternak, G, Kurinov, I, Sicheri, F. | 登録日 | 2019-10-30 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.288 Å) | 主引用文献 | Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat.Chem.Biol., 16, 2020
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8BW9
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8BW8
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8D6D
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39 | 分子名称: | (1P)-2-amino-5-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8D6C
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28 | 分子名称: | (1P)-2-amino-6-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8D6E
| Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306 | 分子名称: | (1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8D6F
| Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41 | 分子名称: | (1M)-2-amino-1-(5-hydroxy-2-methylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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3LJ1
| IRE1 complexed with Cdk1/2 Inhibitor III | 分子名称: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Lee, K.P.K, Sicheri, F. | 登録日 | 2010-01-25 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
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5IBK
| Skp1-F-box in complex with a ubiquitin variant | 分子名称: | F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 | 著者 | Orlicky, S, Sicheri, F. | 登録日 | 2016-02-22 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113, 2016
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5J26
| Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant | 分子名称: | Tumor suppressor p53-binding protein 1, Ubiquitin Variant i53 | 著者 | Wan, L, Canny, M, Juang, Y.C, Durocher, D, Sicheri, F. | 登録日 | 2016-03-29 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.5047 Å) | 主引用文献 | A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing To Be Published
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5JMV
| Crystal structure of mjKae1-pfuPcc1 complex | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein, ... | 著者 | Wan, L, Sicheri, F. | 登録日 | 2016-04-29 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.3864696 Å) | 主引用文献 | Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Nucleic Acids Res., 44, 2016
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4K25
| Crystal Structure of yeast Qri7 homodimer | 分子名称: | CALCIUM ION, Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ... | 著者 | Neculai, D, Wan, L, Mao, D.Y, Sicheri, F. | 登録日 | 2013-04-08 | 公開日 | 2013-05-08 | 最終更新日 | 2013-08-07 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res., 41, 2013
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4DDI
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