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8G9E
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BU of 8g9e by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and 5-(PCF2P)-IP5, an analog of 5-IP7
Descriptor: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2023-02-21
Release date:2024-01-03
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.
Chemistry, 29, 2023
6BYF
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BU of 6byf by Molmil
Crystal structure of the core catalytic domain of PP-IP phosphatase SIW14 from S. cerevisiae in complex with citrate
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2017-12-20
Release date:2018-03-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.
J. Biol. Chem., 293, 2018
5BYB
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BU of 5byb by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PA)2-IP4
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2015-06-10
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthetic tools for studying the chemical biology of InsP8.
Chem.Commun.(Camb.), 51, 2015
7TN5
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BU of 7tn5 by Molmil
Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 (ITPK1)
Descriptor: CHLORIDE ION, Inositol-tetrakisphosphate 1-kinase 1
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
7TN6
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BU of 7tn6 by Molmil
Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1-H192A)
Descriptor: CHLORIDE ION, Inositol-tetrakisphosphate 1-kinase 1
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
7TN4
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BU of 7tn4 by Molmil
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 3-diphosphoinositol 1,2,4,5-tetrakisphosphate (3-PP-IP4), Mg and Fluoride ion
Descriptor: (1R,2S,3R,4R,5S,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
7TN8
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BU of 7tn8 by Molmil
Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1-H192A) in complex with InsP6
Descriptor: CHLORIDE ION, INOSITOL HEXAKISPHOSPHATE, Inositol-tetrakisphosphate 1-kinase 1
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
7TN3
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BU of 7tn3 by Molmil
Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1-F189A/H192A)
Descriptor: CHLORIDE ION, Inositol-tetrakisphosphate 1-kinase 1
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
7TN7
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BU of 7tn7 by Molmil
Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1 residues 18-218-Gly-Ser-Gly-Ser-Gly-248-328)
Descriptor: CHLORIDE ION, Inositol-tetrakisphosphate 1-kinase 1, PHOSPHATE ION
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2022-01-20
Release date:2022-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs.
Faseb J., 36, 2022
3T9B
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BU of 3t9b by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 5.2
Descriptor: Inositol Pyrophosphate Kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T99
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BU of 3t99 by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and in the absence of cadmium at pH 7.0
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Inositol Pyrophosphate Kinase, MAGNESIUM ION
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T54
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BU of 3t54 by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ATP and Cadmium
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Inositol Pyrophosphate Kinase
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-07-26
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T7A
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BU of 3t7a by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-07-29
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9F
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BU of 3t9f by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)
Descriptor: (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9C
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BU of 3t9c by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and inositol hexakisphosphate (IP6)
Descriptor: INOSITOL HEXAKISPHOSPHATE, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9D
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BU of 3t9d by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and 5-(PP)-IP5 (5-IP7)
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9E
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BU of 3t9e by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP, 5-(PP)-IP5 (5-IP7) and MgF3 (transition state mimic)
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, ADENOSINE-5'-DIPHOSPHATE, Inositol Pyrophosphate Kinase, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9A
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BU of 3t9a by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 7.0
Descriptor: CADMIUM ION, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
5BYA
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BU of 5bya by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2015-06-10
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthetic tools for studying the chemical biology of InsP8.
Chem.Commun.(Camb.), 51, 2015
5W2G
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BU of 5w2g by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase
Descriptor: Inositol polyphosphate multikinase,Inositol polyphosphate multikinase
Authors:Wang, H, Shears, S.B.
Deposit date:2017-06-06
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J. Biol. Chem., 292, 2017
5W2H
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BU of 5w2h by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2017-06-06
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J. Biol. Chem., 292, 2017
5W2I
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BU of 5w2i by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2017-06-06
Release date:2017-09-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J. Biol. Chem., 292, 2017
5DGH
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BU of 5dgh by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and 5-(PCP)-IP5
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2015-08-27
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.
Chemistry, 22, 2016
5DGI
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BU of 5dgi by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 3,5-(PCP)2-IP4
Descriptor: 1,2-ETHANEDIOL, 3,5-di-methylenebisphosphonate inositol tetrakisphosphate, ACETATE ION, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2015-08-27
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.
Chemistry, 22, 2016
8T96
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BU of 8t96 by Molmil
Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-IP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinase, MAGNESIUM ION, ...
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2023-06-23
Release date:2023-11-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus.
Embo J., 43, 2024

 

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