5BYA

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4

Summary for 5BYA

Entry DOI	10.2210/pdb5bya/pdb
Related	5BYB
Descriptor	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ADENOSINE-5'-DIPHOSPHATE, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl)methanediyl]}bis(phosphonic acid), ... (7 entities in total)
Functional Keywords	methylenebisphosphonate, phosphonoacetate, non-hydrolyzable, pyrophosphate mimics, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : O43314
Total number of polymer chains	1
Total formula weight	39480.18
Authors	Wang, H.,Shears, S.B. (deposition date: 2015-06-10, release date: 2015-07-22, Last modification date: 2023-09-27)
Primary citation	Riley, A.M.,Wang, H.,Shears, S.B.,L Potter, B.V. Synthetic tools for studying the chemical biology of InsP8. Chem.Commun.(Camb.), 51:12605-12608, 2015 Cited by PubMed: 26153667 DOI: 10.1039/c5cc05017k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation