Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BYA

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000829	molecular_function	diphosphoinositol pentakisphosphate kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue ADP A 401

Chain	Residue
A	ARG134
A	MET240
A	ASP246
A	SER264
A	PRO265
A	ASP309
A	LEU311
A	CYS320
A	ASP321
A	4WZ402
A	MG403
A	PRO149
A	MG404
A	HOH524
A	HOH568
A	HOH596
A	HOH599
A	HOH657
A	HOH720
A	VAL185
A	LYS187
A	HIS194
A	LEU211
A	GLU237
A	GLU238
A	PHE239

site_id	AC2
Number of Residues	35
Details	binding site for residue 4WZ A 402

Chain	Residue
A	LYS53
A	LYS54
A	ARG213
A	LYS214
A	LYS248
A	ARG262
A	ASP309
A	ASP321
A	ASN323
A	SER326
A	LYS329
A	ADP401
A	MG404
A	MG406
A	EDO410
A	HOH528
A	HOH543
A	HOH546
A	HOH554
A	HOH568
A	HOH569
A	HOH575
A	HOH596
A	HOH597
A	HOH613
A	HOH618
A	HOH620
A	HOH657
A	HOH669
A	HOH674
A	HOH719
A	HOH736
A	HOH740
A	HOH748
A	HOH776

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	ASP321
A	ASN323
A	ADP401
A	HOH596
A	HOH599

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 404

Chain	Residue
A	ASP309
A	ASP321
A	ADP401
A	4WZ402
A	HOH568

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 405

Chain	Residue
A	SER68
A	PHE70
A	ILE73
A	HOH590
A	HOH804
A	HOH816

site_id	AC6
Number of Residues	4
Details	binding site for residue MG A 406

Chain	Residue
A	4WZ402
A	HOH657
A	HOH719
A	HOH740

site_id	AC7
Number of Residues	6
Details	binding site for residue MG A 407

Chain	Residue
A	HOH519
A	HOH563
A	HOH597
A	HOH664
A	HOH713
A	HOH885

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 408

Chain	Residue
A	ASN90
A	TRP91
A	PRO92
A	PRO283
A	ILE285
A	HOH644
A	HOH678
A	HOH741

site_id	AC9
Number of Residues	5
Details	binding site for residue ACT A 409

Chain	Residue
A	HOH571
A	SER217
A	ARG218
A	LEU292
A	TRP295

site_id	AD1
Number of Residues	9
Details	binding site for residue EDO A 410

Chain	Residue
A	LYS248
A	VAL249
A	TYR250
A	GLY307
A	PHE308
A	ASP309
A	ASN323
A	SER326
A	4WZ402

site_id	AD2
Number of Residues	8
Details	binding site for residue EDO A 411

Chain	Residue
A	ARG312
A	ALA313
A	GLY315
A	GLN316
A	SER317
A	HOH509
A	HOH703
A	HOH762

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 412

Chain	Residue
A	ASN90
A	TYR256
A	HIS258
A	TYR334
A	HOH501
A	HOH770

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO A 414

Chain	Residue
A	PHE105
A	PRO106
A	LEU107
A	ASP108
A	HOH503
A	HOH647
A	HOH670

site_id	AD5
Number of Residues	7
Details	binding site for residue ACT A 415

Chain	Residue
A	HIS101
A	GLN128
A	ILE131
A	GLN132
A	HOH519
A	HOH526
A	HOH688

site_id	AD6
Number of Residues	6
Details	binding site for residue ACT A 416

Chain	Residue
A	VAL121
A	ASP124
A	LEU125
A	ASN126
A	HOH530
A	HOH679

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)