5BYB

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PA)2-IP4

Summary for 5BYB

Entry DOI	10.2210/pdb5byb/pdb
Related	5BYA
Descriptor	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ADENOSINE-5'-DIPHOSPHATE, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}bis(phosphonic acid), ... (7 entities in total)
Functional Keywords	methylenebisphosphonate, phosphonoacetate, non-hydrolyzable, pyrophosphate mimics, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : O43314
Total number of polymer chains	1
Total formula weight	39238.52
Authors	Wang, H.,Shears, S.B. (deposition date: 2015-06-10, release date: 2015-07-22, Last modification date: 2023-09-27)
Primary citation	Riley, A.M.,Wang, H.,Shears, S.B.,L Potter, B.V. Synthetic tools for studying the chemical biology of InsP8. Chem.Commun.(Camb.), 51:12605-12608, 2015 Cited by PubMed Abstract: To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism. PubMed: 26153667 DOI: 10.1039/c5cc05017k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation