6M8B
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with kaempferol
Summary for 6M8B
| Entry DOI | 10.2210/pdb6m8b/pdb |
| Related | 5w2g |
| Descriptor | Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE (3 entities in total) |
| Functional Keywords | kinase, inositol, inositol polyphosphate, transferase, kaempferol, flavonoid, inhibitor, natural product, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 30114.15 |
| Authors | Wang, H.,Shears, S.B. (deposition date: 2018-08-21, release date: 2019-01-23, Last modification date: 2023-10-11) |
| Primary citation | Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.,Chakraborty, M.,Chakraborty, A.,Frye, S.V.,Pearce, K.H.,Wang, X.,Shears, S.B.,Wang, H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J. Med. Chem., 62:1443-1454, 2019 Cited by PubMed: 30624931DOI: 10.1021/acs.jmedchem.8b01593 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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