6N5C
Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PCF2Am-InsP5
Summary for 6N5C
| Entry DOI | 10.2210/pdb6n5c/pdb |
| Descriptor | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | inositol, inositol polyphosphate, inositol pyrophosphate, analog, phosphonodifluoroacetamide, diphosphoinositol pentakisphosphate, kinase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 39396.85 |
| Authors | Wang, H.,Shears, S.B.,Riley, A.,Potter, B. (deposition date: 2018-11-21, release date: 2019-08-21, Last modification date: 2023-10-11) |
| Primary citation | Riley, A.M.,Wang, H.,Shears, S.B.,Potter, B.V.L. Synthesis of an alpha-phosphono-alpha , alpha-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7. Medchemcomm, 10:1165-1172, 2019 Cited by PubMed: 31391889DOI: 10.1039/c9md00163h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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