6N5C

Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PCF2Am-InsP5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000829	molecular_function	diphosphoinositol pentakisphosphate kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue ANP A 401

Chain	Residue
A	ARG134
A	PHE239
A	MET240
A	ASP246
A	SER264
A	ASP309
A	LEU311
A	CYS320
A	ASP321
A	ASN323
A	MG402
A	PRO149
A	MG403
A	KDJ406
A	HOH523
A	HOH565
A	HOH569
A	HOH572
A	HOH704
A	VAL185
A	LYS187
A	HIS194
A	LEU211
A	ARG213
A	GLU237
A	GLU238

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	ASP321
A	ASN323
A	ANP401
A	HOH600

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 403

Chain	Residue
A	ASP309
A	ASP321
A	ANP401
A	HOH565

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 404

Chain	Residue
A	SER68
A	PHE70
A	ILE73
A	HOH543
A	HOH699
A	HOH740

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 405

Chain	Residue
A	HOH524
A	HOH559
A	HOH562
A	HOH690
A	HOH747
A	HOH753

---

site_id	AC6
Number of Residues	24
Details	binding site for residue KDJ A 406

Chain	Residue
A	LYS53
A	LYS54
A	ARG213
A	LYS214
A	LYS248
A	ARG262
A	ARG273
A	SER326
A	LYS329
A	ANP401
A	EDO410
A	HOH510
A	HOH515
A	HOH523
A	HOH524
A	HOH525
A	HOH553
A	HOH562
A	HOH575
A	HOH601
A	HOH605
A	HOH651
A	HOH657
A	HOH668

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT A 407

Chain	Residue
A	VAL121
A	ASP124
A	LEU125
A	ASN126
A	HOH521
A	HOH624

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 408

Chain	Residue
A	ASN90
A	TRP91
A	PRO92
A	ILE285
A	HOH638
A	HOH667
A	HOH703

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ACT A 409

Chain	Residue
A	SER217
A	ARG218
A	LEU292
A	HOH555

---

site_id	AD1
Number of Residues	9
Details	binding site for residue EDO A 410

Chain	Residue
A	LYS248
A	VAL249
A	TYR250
A	GLY307
A	PHE308
A	ASP309
A	ASN323
A	SER326
A	KDJ406

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 411

Chain	Residue
A	GLN316
A	SER317
A	HOH514
A	ARG312
A	ALA313
A	GLY315

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 412

Chain	Residue
A	ASN90
A	TYR256
A	HIS258
A	HOH584

---

site_id	AD4
Number of Residues	2
Details	binding site for residue ACT A 413

Chain	Residue
A	PHE70
A	HOH673

---

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO A 414

Chain	Residue
A	PHE105
A	PRO106
A	LEU107
A	ASP108
A	HOH517
A	HOH574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---