6N5C
Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PCF2Am-InsP5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | polymer | 330 | 37568.9 | 1 | UniProt (O43314) Pfam (PF18086) | Homo sapiens (Human) | Diphosphoinositol pentakisphosphate kinase 2,Histidine acid phosphatase domain-containing protein 1,InsP6 and PP-IP5 kinase 2,VIP1 homolog 2,hsVIP2 |
| 2 | B (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | C, D, E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G (A) | (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid | non-polymer | 737.1 | 1 | Chemie (KDJ) | |||
| 5 | H, J, N (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | I, K, L, M, O (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | P (A) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A: 41 - 366 (UniProt: O43314)
| PDB | External Database | Details |
|---|---|---|
| Gly 37 | - | expression tag |
| Ser 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Thr 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37568.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1828.0 | |
| All* | Total formula weight | 39396.8 |
