4QI0
| X-ray structure of the ROQ domain from murine Roquin-1 | Descriptor: | 1,2-ETHANEDIOL, Roquin-1 | Authors: | Janowski, R, Schlundt, A, Sattler, M, Niessing, D. | Deposit date: | 2014-05-30 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nat.Struct.Mol.Biol., 21, 2014
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7NDX
| Crystal structure of the human HSP40 DNAJB1-CTDs in complex with a peptide of NudC | Descriptor: | 1,2-ETHANEDIOL, DnaJ homolog subfamily B member 1, Nuclear migration protein nudC | Authors: | Delhommel, F, Zak, K.M, Popowicz, G.M, Sattler, M. | Deposit date: | 2021-02-02 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.541 Å) | Cite: | NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Mol.Cell, 82, 2022
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2JXC
| Structure of the EPS15-EH2 Stonin2 Complex | Descriptor: | CALCIUM ION, Epidermal growth factor receptor substrate 15, Stonin-2 | Authors: | Rumpf, J, Simon, B, Jung, N, Maritzen, T, Haucke, V, Sattler, M, Groemping, Y. | Deposit date: | 2007-11-12 | Release date: | 2008-01-08 | Last modified: | 2013-06-19 | Method: | SOLUTION NMR | Cite: | Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. Embo J., 27, 2008
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1MHN
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2L1L
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1KKS
| Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression | Descriptor: | 5'-R(*GP*GP*AP*AP*GP*GP*CP*CP*CP*UP*UP*UP*UP*CP*AP*GP*GP*GP*CP*CP*AP*CP*CP*C)-3' | Authors: | Zanier, K, Luyten, I, Crombie, C, Muller, B, Schuemperli, D, Linge, J.P, Nilges, M, Sattler, M. | Deposit date: | 2001-12-10 | Release date: | 2002-03-13 | Last modified: | 2018-01-24 | Method: | SOLUTION NMR | Cite: | Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression. RNA, 8, 2002
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1T2R
| Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain | Descriptor: | 5'-R(*CP*UP*CP*AP*C)-3', Argonaute 2 | Authors: | Lingel, A, Simon, B, Izaurralde, E, Sattler, M. | Deposit date: | 2004-04-22 | Release date: | 2004-06-01 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004
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1T2S
| Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain | Descriptor: | 5'-D(*CP*TP*CP*AP*C)-3', Argonaute 2 | Authors: | Lingel, A, Simon, B, Izaurralde, E, Sattler, M. | Deposit date: | 2004-04-22 | Release date: | 2004-06-01 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004
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1O6W
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5O3J
| Crystal structure of TIA-1 RRM2 in complex with RNA | Descriptor: | Nucleolysin TIA-1 isoform p40, RNA (5'-R(P*UP*UP*C)-3') | Authors: | Sonntag, M, Jagtap, P.K.A, Hennig, J, Sattler, M. | Deposit date: | 2017-05-24 | Release date: | 2017-07-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins. Angew. Chem. Int. Ed. Engl., 56, 2017
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5OML
| Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules to investigate the water envelope | Descriptor: | (3~{R})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid, BETA-MERCAPTOETHANOL, Peroxin 14, ... | Authors: | Ratkova, E.L, Dawidowski, M, Napolitano, V, Dubin, G, Fino, R, Popowicz, G, Sattler, M, Tetko, I.V. | Deposit date: | 2017-08-01 | Release date: | 2019-03-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules to investigate the water envelope To Be Published
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3NC0
| Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II) | Descriptor: | DI(HYDROXYETHYL)ETHER, Exportin-1, GLYCEROL, ... | Authors: | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | Deposit date: | 2010-06-04 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
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3NBY
| Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | Deposit date: | 2010-06-04 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
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3NBZ
| Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I) | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | Deposit date: | 2010-06-04 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
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3NC1
| Crystal structure of the CRM1-RanGTP complex | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | Deposit date: | 2010-06-04 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
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4Q9B
| IgNAR antibody domain C2 | Descriptor: | Novel antigen receptor | Authors: | Feige, J.M, Graewert, M.A, Marcinowski, M, Hennig, J, Behnke, J, Auslaender, D, Herold, E.M, Peschek, J, Castro, C.D, Flajnik, M.F, Hendershot, L.M, Sattler, M, Groll, M, Buchner, J. | Deposit date: | 2014-04-30 | Release date: | 2014-07-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proc.Natl.Acad.Sci.USA, 111, 2014
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1SHC
| SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | SHC, TRKA RECEPTOR PHOSPHOPEPTIDE | Authors: | Zhou, M.-M, Ravichandran, K.S, Olejniczak, E.T, Petros, A.M, Meadows, R.P, Sattler, M, Harlan, J.E, Wade, W.S, Burakoff, S.J, Fesik, S.W. | Deposit date: | 1996-03-27 | Release date: | 1997-05-15 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature, 378, 1995
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6R8G
| Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine | Descriptor: | 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | Deposit date: | 2019-04-01 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity Commun Biol, 2021
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6SPT
| High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity | Descriptor: | 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | Authors: | Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G. | Deposit date: | 2019-09-02 | Release date: | 2020-01-01 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity. J.Med.Chem., 63, 2020
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5NPA
| Solution structure of Drosophila melanogaster Loquacious dsRBD2 | Descriptor: | Loquacious | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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5NPG
| Solution structure of Drosophila melanogaster Loquacious dsRBD1 | Descriptor: | Loquacious, isoform F | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Hartlmuller, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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1O0P
| Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide | Descriptor: | Splicing Factor SF1, Splicing factor U2AF 65 kDa subunit | Authors: | Selenko, P, Gregorovic, G, Sprangers, R, Stier, G, Rhani, Z, Kramer, A, Sattler, M. | Deposit date: | 2003-02-24 | Release date: | 2003-05-06 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural Basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP Mol.Cell, 11, 2003
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5L87
| Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases. | Descriptor: | 1,2-ETHANEDIOL, 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, Peroxin 14 | Authors: | Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M. | Deposit date: | 2016-06-07 | Release date: | 2017-03-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (0.87 Å) | Cite: | Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355, 2017
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2MKL
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5L8A
| Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases. | Descriptor: | 1,2-ETHANEDIOL, 1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(phenylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, GLYCINE, ... | Authors: | Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M. | Deposit date: | 2016-06-07 | Release date: | 2017-03-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355, 2017
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