8U27
 
 | | Bcl-2-xL complexed with compound 35 | | Descriptor: | Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate | | Authors: | Rizo, J, Pan, Y.-Z. | | Deposit date: | 2023-09-05 | | Release date: | 2023-09-13 | | Last modified: | 2023-11-08 | | Method: | SOLUTION NMR | | Cite: | Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Commun Biol, 6, 2023
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7UDB
 | | Cryo-EM structure of a synaptobrevin-Munc18-1-syntaxin-1 complex class 2 | | Descriptor: | Synaptobrevin-2, Syntaxin-1A, Syntaxin-binding protein 1 | | Authors: | Rizo, J, Bai, X, Stepien, K.P, Xu, J, Zhang, X. | | Deposit date: | 2022-03-18 | | Release date: | 2022-04-06 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Sci Adv, 8, 2022
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7UDC
 | | cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex class1 | | Descriptor: | Synaptobrevin-2, Syntaxin-1A, Syntaxin-binding protein 1 | | Authors: | Rizo, J, Bai, X, Stepien, K.P, Xu, J, Zhang, X. | | Deposit date: | 2022-03-18 | | Release date: | 2022-04-06 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Sci Adv, 8, 2022
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4OMO
 | | Crystal structure of the c-Src tyrosine kinase SH3 domain mutant Q128E | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Camara-Artigas, A, Bacarizo, J. | | Deposit date: | 2014-01-27 | | Release date: | 2014-12-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation.
Plos One, 9, 2014
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4OMN
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4OMP
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4QT7
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4OML
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5UF7
 | | CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN | | Descriptor: | Protein unc-13 homolog A | | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | | Deposit date: | 2017-01-03 | | Release date: | 2017-02-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.896 Å) | | Cite: | Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Elife, 6, 2017
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5UE8
 | | The crystal structure of Munc13-1 C1C2BMUN domain | | Descriptor: | CHLORIDE ION, Protein unc-13 homolog A, ZINC ION | | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | | Deposit date: | 2016-12-29 | | Release date: | 2017-02-15 | | Last modified: | 2018-03-28 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Elife, 6, 2017
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4NPJ
 | | Extended-Synaptotagmin 2, C2A- and C2B-domains | | Descriptor: | ACETATE ION, CHLORIDE ION, Extended synaptotagmin-2, ... | | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | | Deposit date: | 2013-11-21 | | Release date: | 2014-01-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2.
Structure, 22, 2014
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4Y21
 | | Crystal Structure of Munc13-1 MUN domain | | Descriptor: | Protein unc-13 homolog A | | Authors: | Yang, X.Y, Wang, S, Sheng, Y, Zhang, M, Zou, W.J, Wu, L.J, Kang, L.J, Rizo, J, Zhang, R.G, Xu, T, Ma, C. | | Deposit date: | 2015-02-09 | | Release date: | 2015-06-10 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
Nat.Struct.Mol.Biol., 22, 2015
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6ANK
 | | Synaptotagmin-7, C2A- and C2B-domains | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7 | | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | | Deposit date: | 2017-08-13 | | Release date: | 2017-09-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.254 Å) | | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ANJ
 | | Synaptotagmin-7, C2A domain | | Descriptor: | ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... | | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | | Deposit date: | 2017-08-13 | | Release date: | 2017-09-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1BR0
 | | THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A | | Descriptor: | PROTEIN (SYNTAXIN 1-A) | | Authors: | Fernandez, I, Ubach, J, Dubulova, I, Zhang, X, Sudhof, T.C, Rizo, J. | | Deposit date: | 1998-08-25 | | Release date: | 1998-09-02 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.
Cell(Cambridge,Mass.), 94, 1998
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2CJS
 | | Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2, ... | | Authors: | Lu, J, Machius, M, Dulubova, I, Dai, H, Sudhof, T.C, Tomchick, D.R, Rizo, J. | | Deposit date: | 2006-04-06 | | Release date: | 2006-06-07 | | Last modified: | 2019-01-30 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Basis for a Munc13-1 Homodimer to Munc13-1/Rim Heterodimer Switch.
Plos Biol., 4, 2006
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2CJT
 | | Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, UNC-13 HOMOLOG A | | Authors: | Lu, J, Machius, M, Dulubova, I, Dai, H, Sudhof, T.C, Tomchick, D.R, Rizo, J. | | Deposit date: | 2006-04-06 | | Release date: | 2006-06-07 | | Last modified: | 2019-01-30 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Structural Basis for a Munc13-1 Dimeric to Munc13-1/Rim Heterodimer Switch
Plos Biol., 4, 2006
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3SWH
 | | Munc13-1, MUN domain, C-terminal module | | Descriptor: | Protein unc-13 homolog A | | Authors: | Tomchick, D.R, Rizo, J, Li, W. | | Deposit date: | 2011-07-13 | | Release date: | 2011-11-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors.
Structure, 19, 2011
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1S2H
 | | The Mad2 spindle checkpoint protein possesses two distinct natively folded states | | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2A | | Authors: | Luo, X, Tang, Z, Xia, G, Wassmann, K, Matsumoto, T, Rizo, J, Yu, H. | | Deposit date: | 2004-01-08 | | Release date: | 2004-03-30 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat.Struct.Mol.Biol., 11, 2004
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1BYN
 | | SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I | | Descriptor: | CALCIUM ION, PROTEIN (SYNAPTOTAGMIN I) | | Authors: | Shao, X, Fernandez, I, Sudhof, T.C, Rizo, J. | | Deposit date: | 1998-10-18 | | Release date: | 1998-10-21 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
Biochemistry, 37, 1998
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1EHS
 | | THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM | | Descriptor: | HEAT-STABLE ENTEROTOXIN B | | Authors: | Sukumar, M, Rizo, J, Wall, M, Dreyfus, L.A, Kupersztoch, Y.M, Gierasch, L.M. | | Deposit date: | 1995-06-13 | | Release date: | 1995-09-15 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.
Protein Sci., 4, 1995
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3RPB
 | | THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN | | Descriptor: | RABPHILIN 3-A | | Authors: | Ubach, J, Garcia, J, Nittler, M.P, Sudhof, T.C, Rizo, J. | | Deposit date: | 1999-04-19 | | Release date: | 1999-12-23 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of the Janus-faced C2B domain of rabphilin.
Nat.Cell Biol., 1, 1999
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2JQQ
 | | Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p) | | Descriptor: | Conserved oligomeric Golgi complex subunit 2 | | Authors: | Cavanaugh, L.F, Chen, X, Pelczer, I, Rizo, J, Hughson, F.M. | | Deposit date: | 2007-06-06 | | Release date: | 2007-06-19 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of conserved oligomeric Golgi complex subunit 2
J.Biol.Chem., 282, 2007
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3OGM
 | | Structure of COI1-ASK1 in complex with coronatine and the JAZ1 degron | | Descriptor: | (1S,2S)-2-ethyl-1-({[(3aS,4S,6R,7aS)-6-ethyl-1-oxooctahydro-1H-inden-4-yl]carbonyl}amino)cyclopropanecarboxylic acid, Coronatine-insensitive protein 1, JAZ1 degron peptide, ... | | Authors: | Sheard, L.B, Tan, X, Mao, H, Withers, J, Ben-Nissan, G, Hinds, T.R, Hsu, F, Sharon, M, Browse, J, He, S.Y, Rizo, J, Howe, G.A, Zheng, N. | | Deposit date: | 2010-08-17 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
Nature, 468, 2010
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3OGL
 | | Structure of COI1-ASK1 in complex with JA-isoleucine and the JAZ1 degron | | Descriptor: | Coronatine-insensitive protein 1, JAZ1 incomplete degron peptide, N-({(1R,2S)-3-oxo-2-[(2Z)-pent-2-en-1-yl]cyclopentyl}acetyl)-L-isoleucine, ... | | Authors: | Sheard, L.B, Tan, X, Mao, H, Withers, J, Ben-Nissan, G, Hinds, T.R, Hsu, F, Sharon, M, Browse, J, He, S.Y, Rizo, J, Howe, G.A, Zheng, N. | | Deposit date: | 2010-08-17 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
Nature, 468, 2010
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