2CJS

Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules

Summary for 2CJS

Entry DOI	10.2210/pdb2cjs/pdb
Related	1Y8F 2A20 2BWQ 2CJT
Descriptor	UNC-13 HOMOLOG A, REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	neurotransmitter transport, exocytosis, zinc finger, synaptosome, phorbol-ester binding, neurotransmitter release, metal-binding, protein- protein interactions, rim, munc13, synapse, transport, c2 domains
Biological source	RATTUS NORVEGICUS (RAT) More
Total number of polymer chains	3
Total formula weight	45004.69
Authors	Lu, J.,Machius, M.,Dulubova, I.,Dai, H.,Sudhof, T.C.,Tomchick, D.R.,Rizo, J. (deposition date: 2006-04-06, release date: 2006-06-07, Last modification date: 2019-01-30)
Primary citation	Lu, J.,Machius, M.,Dulubova, I.,Dai, H.,Sudhof, T.C.,Tomchick, D.R.,Rizo, J. Structural Basis for a Munc13-1 Homodimer to Munc13-1/Rim Heterodimer Switch. Plos Biol., 4:E192-, 2006 Cited by PubMed: 16732694 DOI: 10.1371/JOURNAL.PBIO.0040192 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation