2CJS

Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	UNC-13 HOMOLOG A	polymer	167	18570.0	2	UniProt (Q62768) Pfam (PF00168)	RATTUS NORVEGICUS (RAT)	MUNC13-1
2	C (C)	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2	polymer	62	6870.9	1	UniProt (Q9JIS1) Pfam (PF22601)	RATTUS NORVEGICUS (RAT)	RIM2ALPHA, RAB3-INTERACTING MOLECULE 2, RIM 2
3	D, E, I, N, O (A, B, C)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4	F, G, H, J, K... (A, B, C)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	L, M (C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	Q, R, S (A, B, C)	water	water		18.0	340	Chemie (HOH)

Sequence modifications

A, B: -11 - 1 (PDB: 2CJS)
A, B: 151 - 155 (PDB: 2CJS)
A, B: 2 - 150 (UniProt: Q62768)

PDB	External Database	Details
Glu 32	Lys 32	engineered mutation

C: 81 - 82 (PDB: 2CJS)
C: 83 - 142 (UniProt: Q9JIS1)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	44011.0
Non-Polymers*	Number of molecules	13
	Total formula weight	993.7
All*	Total formula weight	45004.7

*Water molecules are not included.