3EEI
 
 | | Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A | | 分子名称: | (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase | | 著者 | Ho, M, Rinaldo-matthis, A, Brown, R.L, Norris, G.E, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L. | | 登録日 | 2008-09-04 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A
To be Published
|
|
4L2L
 | | Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine | | 分子名称: | 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETATE ION, Leukotriene A-4 hydrolase, ... | | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-06-04 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4MKT
 | | Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine | | 分子名称: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETIC ACID, ... | | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-09-05 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.618 Å) | | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4MS6
 | | Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue | | 分子名称: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ACETIC ACID, Leukotriene A-4 hydrolase, ... | | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-09-18 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4JC7
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-21 | | 公開日 | 2014-01-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
|
|
4JCZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-22 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
|
|
4JRZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-03-22 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
|
|
4J7T
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-14 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.203 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
|
|
4J7Y
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | D-gamma-glutamyl-(Z)-N-(carboxymethylidene)-S-[(2R)-2-hydroxy-4-phenylbutyl]-L-cysteinamide, Leukotriene C4 synthase, NICKEL (II) ION, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-14 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
|
|
1Z4Q
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with 2',3'-dideoxy-2',3-didehydrothymidine 5'-monophosphate (d4T-MP) | | 分子名称: | 5'(3')-deoxyribonucleotidase, MAGNESIUM ION, [(5R)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2,5-DIHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4I
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with deoxyribouridine 5'-monophosphate | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5'(3')-deoxyribonucleotidase, GLYCEROL, ... | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4J
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with uridine 2'-monophosphate | | 分子名称: | 5'(3')-deoxyribonucleotidase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4L
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 5'-monophosphate | | 分子名称: | 5'(3')-deoxyribonucleotidase, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4K
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3'-monophosphate | | 分子名称: | 5'(3')-deoxyribonucleotidase, MAGNESIUM ION, THYMIDINE-3'-PHOSPHATE | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4P
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with deoxyriboguanosine 5'-monophosphate | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, 5'(3')-deoxyribonucleotidase, MAGNESIUM ION | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
1Z4M
 | | Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with uridine 5'-monophosphate | | 分子名称: | 5'(3')-deoxyribonucleotidase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Wallden, K, Ruzzenente, B, Rinaldo-Matthis, A, Bianchi, V, Nordlund, P. | | 登録日 | 2005-03-16 | | 公開日 | 2005-07-26 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
STRUCTURE, 13, 2005
|
|
3BGS
 | | Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate | | 分子名称: | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, purine nucleoside phosphorylase | | 著者 | Murkin, A.S, Ramagopal, U.A, Almo, S.C, Schramm, V.L. | | 登録日 | 2007-11-27 | | 公開日 | 2008-01-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase
J.Am.Chem.Soc., 130, 2008
|
|
5DK6
 | | CRYSTAL STRUCTURE OF A 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE (MTA/SAH) NUCLEOSIDASE (MTAN) FROM COLWELLIA PSYCHRERYTHRAEA 34H (CPS_4743, TARGET PSI-029300) IN COMPLEX WITH ADENINE AT 2.27 A RESOLUTION | | 分子名称: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE, GLYCINE | | 著者 | Himmel, D.M, Bhosle, R, Toro, R, Ahmed, M, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R.D, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2015-09-03 | | 公開日 | 2015-11-04 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF A 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE (MTA/SAH)NUCLEOSIDASE (MTAN) FROM COLWELLIA PSYCHRERYTHRAEA 34H (CPS_4743, TARGET PSI-029300) IN COMPLEX WITH ADENINE AT 2.27 A RESOLUTION
To be published
|
|
3LOO
 | | Crystal structure of Anopheles gambiae adenosine kinase in complex with P1,P4-di(adenosine-5) tetraphosphate | | 分子名称: | Anopheles gambiae adenosine kinase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CHLORIDE ION, ... | | 著者 | Ho, M.-C, Cassera, M.B, Almo, S.C, Schramm, V.L. | | 登録日 | 2010-02-04 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A High-Affinity Adenosine Kinase from Anopheles gambiae.
Biochemistry, 50, 2011
|
|
6SSS
 | | Crystal structure of Human Microsomal Glutathione S-Transferase 2 | | 分子名称: | 1-(8Z-hexadecenoyl)-sn-glycerol, GLYCEROL, Microsomal glutathione S-transferase 2, ... | | 著者 | Thulasingam, M, Nji, E, Haeggstrom, J.Z. | | 登録日 | 2019-09-09 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.498 Å) | | 主引用文献 | Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
|
|
6SSU
 | |
6SSW
 | |
3DHZ
 | |
4DPR
 | | Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril | | 分子名称: | ACETIC ACID, GLYCEROL, L-CAPTOPRIL, ... | | 著者 | Stsiapanava, A, Haeggstrom, J.Z, Rinaldo-Matthis, A. | | 登録日 | 2012-02-14 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Capturing LTA4hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4synthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
2JAO
 | | Crystal structure of D12N variant of mouse cytosolic 5'(3')- deoxyribonucleotidase (cdN) in complex with deoxyguanosine 5'- monophosphate | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, 5'(3')-DEOXYRIBONUCLEOTIDASE, GLYCEROL, ... | | 著者 | Wallden, K, Ruzzenente, B, Bianchi, V, Nordlund, P. | | 登録日 | 2006-11-29 | | 公開日 | 2007-11-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues.
Biochemistry, 46, 2007
|
|
