1T3D
 
 | | Crystal structure of Serine Acetyltransferase from E.coli at 2.2A | | Descriptor: | CYSTEINE, Serine acetyltransferase | | Authors: | Pye, V.E, Tingey, A.P, Robson, R.L, Moody, P.C.E. | | Deposit date: | 2004-04-26 | | Release date: | 2004-07-13 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Structure and Mechanism of Serine Acetyltransferase from Escherichia coli
J.Biol.Chem., 279, 2004
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2WU9
 | | Crystal structure of peroxisomal KAT2 from Arabidopsis thaliana | | Descriptor: | 1,2-ETHANEDIOL, 3-KETOACYL-COA THIOLASE 2, PEROXISOMAL | | Authors: | Pye, V.E, Christensen, C.E, Dyer, J.H, Arent, S, Henriksen, A. | | Deposit date: | 2009-10-01 | | Release date: | 2010-05-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Peroxisomal Plant 3-Ketoacyl-Coa Thiolases Structure and Activity are Regulated by a Sensitive Redox Switch
J.Biol.Chem., 285, 2010
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2WUA
 | | Structure of the peroxisomal 3-ketoacyl-CoA thiolase from Sunflower | | Descriptor: | ACETOACETYL COA THIOLASE | | Authors: | Pye, V.E, Christensen, C.E, Dyer, J.H, Arent, S, Henriksen, A. | | Deposit date: | 2009-10-01 | | Release date: | 2010-05-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Peroxisomal Plant 3-Ketoacyl-Coa Thiolases Structure and Activity are Regulated by a Sensitive Redox Switch
J.Biol.Chem., 285, 2010
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6SP2
 | | CryoEM structure of SERINC from Drosophila melanogaster | | Descriptor: | CARDIOLIPIN, Lauryl Maltose Neopentyl Glycol, Membrane protein TMS1d, ... | | Authors: | Pye, V.E, Nans, A, Cherepanov, P. | | Deposit date: | 2019-08-30 | | Release date: | 2020-01-01 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | A bipartite structural organization defines the SERINC family of HIV-1 restriction factors.
Nat.Struct.Mol.Biol., 27, 2020
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7B62
 | | Crystal structure of SARS-CoV-2 spike protein N-terminal domain in complex with biliverdin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Pye, V.E, Rosa, A, Roustan, C, Cherepanov, P. | | Deposit date: | 2020-12-07 | | Release date: | 2021-04-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
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6RNY
 | | PFV intasome - nucleosome strand transfer complex | | Descriptor: | DNA (108-MER), DNA (128-MER), DNA (33-MER), ... | | Authors: | Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. | | Deposit date: | 2019-05-09 | | Release date: | 2019-09-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Nat Commun, 10, 2019
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7ADV
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ447 (compound 6v) | | Descriptor: | 4-azanyl-~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-6-[2-(2-morpholin-4-ylethylsulfonyl)ethyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | | Authors: | Pye, V.E, Cherepanov, P. | | Deposit date: | 2020-09-16 | | Release date: | 2021-03-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.
Acs Infect Dis., 7, 2021
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7ADU
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7Z1Z
 | | MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | | Descriptor: | DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ... | | Authors: | Pye, V.E, Ballandras-Colas, A, Cherepanov, P. | | Deposit date: | 2022-02-25 | | Release date: | 2022-05-11 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
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6R0C
 | | Human-D02 Nucleosome Core Particle with biotin-streptavidin label | | Descriptor: | DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | | Authors: | Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A. | | Deposit date: | 2019-03-12 | | Release date: | 2019-09-25 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Nat Commun, 10, 2019
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4B6D
 | | Structure of the atypical C1 domain of MgcRacGAP | | Descriptor: | GLYCEROL, RAC GTPASE-ACTIVATING PROTEIN 1, ZINC ION | | Authors: | Pye, V.E, Lekomtsev, S, Petronczki, M, Cherepanov, P. | | Deposit date: | 2012-08-09 | | Release date: | 2012-12-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Centralspindlin Links the Mitotic Spindle to the Plasma Membrane During Cytokinesis.
Nature, 492, 2012
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8B7D
 | | Luminal domain of TMEM106B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | | Authors: | Pye, V.E, Roustan, C, Cherepanov, P. | | Deposit date: | 2022-09-29 | | Release date: | 2023-07-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
Cell, 186, 2023
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5MEC
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5MLU
 | | Crystal structure of the PFV GAG CBS bound to a mononucleosome | | Descriptor: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | | Authors: | Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P. | | Deposit date: | 2016-12-07 | | Release date: | 2017-05-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for spumavirus GAG tethering to chromatin.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MEA
 | | Crystal structure of yeast Cdt1 (N terminal and middle domain), form 2. | | Descriptor: | Cell division cycle protein CDT1, GLYCEROL, SULFATE ION | | Authors: | Pye, V.E, Frigola, J, Diffley, J.F.X, Cherepanov, P. | | Deposit date: | 2016-11-14 | | Release date: | 2017-05-17 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.152 Å) | | Cite: | Cdt1 stabilizes an open MCM ring for helicase loading.
Nat Commun, 8, 2017
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5MEB
 | | Crystal structure of yeast Cdt1 C-terminal domain | | Descriptor: | Cell division cycle protein CDT1, SULFATE ION | | Authors: | Pye, V.E, Frigola, J, Diffley, J.F.X, Cherepanov, P. | | Deposit date: | 2016-11-14 | | Release date: | 2017-05-17 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cdt1 stabilizes an open MCM ring for helicase loading.
Nat Commun, 8, 2017
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5NO1
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5ME9
 | | Crystal structure of yeast Cdt1 (N terminal and middle domain), form 1. | | Descriptor: | Cell division cycle protein CDT1, GLYCEROL, SULFATE ION | | Authors: | Pye, V.E, Frigola, J, Diffley, J.F.X, Cherepanov, P. | | Deposit date: | 2016-11-14 | | Release date: | 2017-05-17 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cdt1 stabilizes an open MCM ring for helicase loading.
Nat Commun, 8, 2017
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5M0R
 | | Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex | | Descriptor: | integrase, tDNA, vDNA, ... | | Authors: | Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P. | | Deposit date: | 2016-10-05 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
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5LLJ
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8POE
 | | Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied | | Descriptor: | Autophagy-related protein 9B | | Authors: | Chiduza, G.N, Pye, V.E, Tooze, S.A, Cherepanov, P. | | Deposit date: | 2023-07-04 | | Release date: | 2023-11-15 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.
Autophagy, 20, 2024
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5T3A
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7PEL
 | | CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma | | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | | Authors: | Barski, M, Pye, V.E, Nans, A, Cherepanov, P, Maertens, G.N. | | Deposit date: | 2021-08-10 | | Release date: | 2021-08-25 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.
Nat Commun, 11, 2020
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3ZHF
 | | gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN | | Descriptor: | 1,2-ETHANEDIOL, AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Juergens, M.C, Voros, J, Rautureau, G, Shepherd, D, Pye, V.E, Muldoon, J, Johnson, C.M, Ashcroft, A, Freund, S.M.V, Ferguson, N. | | Deposit date: | 2012-12-21 | | Release date: | 2013-07-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Hepatitis B Virus Pres1 Domain Hijacks Host Trafficking Proteins by Motif Mimicry.
Nat.Chem.Biol., 9, 2013
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7U32
 | | MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution | | Descriptor: | CALCIUM ION, DNA EV272, DNA EV273, ... | | Authors: | Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D. | | Deposit date: | 2022-02-25 | | Release date: | 2022-05-11 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
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