7ADV

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ447 (compound 6v)

Summary for 7ADV

• Entry DOI: 10.2210/pdb7adv/pdb
• Descriptor: Integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (9 entities in total)
• Functional Keywords: integrase, intasome, protein dna complex, insti, drug, hiv, retrovirus, integration, viral protein
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Total number of polymer chains: 4
• Total formula weight: 102819.10

Authors

Pye, V.E.,Cherepanov, P. (deposition date: 2020-09-16, release date: 2021-03-24, Last modification date: 2024-01-31)

• Primary citation: Smith, S.J.,Zhao, X.Z.,Passos, D.O.,Pye, V.E.,Cherepanov, P.,Lyumkis, D.,Burke Jr., T.R.,Hughes, S.H.; HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.; Acs Infect Dis., 7:1469-1482, 2021; PubMed: 33686850; DOI: 10.1021/acsinfecdis.0c00819

Experimental method

X-RAY DIFFRACTION (2.65 Å)