5NO1

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ407 (compound 5g)

Summary for 5NO1

• Entry DOI: 10.2210/pdb5no1/pdb
• Descriptor: Integrase, HEXANE-1,6-DIOL, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... (11 entities in total)
• Functional Keywords: hiv, pfv, prototype foamy virus, integrase, strand transfer, insti, tetramer intasome, integration, inhibitor, drug, viral protein
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Cellular location: Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350
• Total number of polymer chains: 4
• Total formula weight: 102164.76

Authors

Pye, V.E.,Cherepanov, P. (deposition date: 2017-04-10, release date: 2017-08-02, Last modification date: 2024-01-17)

• Primary citation: Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.; Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.; J. Med. Chem., 60:7315-7332, 2017; PubMed: 28737946; DOI: 10.1021/acs.jmedchem.7b00596

Experimental method

X-RAY DIFFRACTION (2.6 Å)