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5NO1

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ407 (compound 5g)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0015074biological_processDNA integration
B0003676molecular_functionnucleic acid binding
B0015074biological_processDNA integration
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue MG A 401
ChainResidue
AASP128
AGLU221
AXZ4403
DHOH201

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 402
ChainResidue
AASP128
AASP185
AXZ4403
AHOH515
AHOH536

site_idAC3
Number of Residues16
Detailsbinding site for residue XZ4 A 403
ChainResidue
AASP128
AASP185
ATYR212
APRO214
AGLN215
AGLU221
AMG401
AMG402
ASO4408
AMES415
AHOH515
AHOH536
CDG4
DDC16
DDA17
DHOH201

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 404
ChainResidue
AHIS62
AHIS66
ACYS96
ACYS99

site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 A 405
ChainResidue
AARG114
ATYR303
APRO305
CDC6
CGOL101

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 A 406
ChainResidue
APRO115
AASP116
CDT3

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 A 407
ChainResidue
ASER136
AGLN137
ALYS241
AHOH501

site_idAC8
Number of Residues8
Detailsbinding site for residue SO4 A 408
ChainResidue
AASP185
AGLN186
AGLY187
APRO211
ATYR212
AXZ4403
AMES415
AHOH527

site_idAC9
Number of Residues5
Detailsbinding site for residue SO4 A 409
ChainResidue
ALYS228
ASER332
ALEU333
AARG336
AHOH504

site_idAD1
Number of Residues4
Detailsbinding site for residue SO4 A 410
ChainResidue
AHIS338
ALYS339
AHIS357
AHOH522

site_idAD2
Number of Residues5
Detailsbinding site for residue GOL A 411
ChainResidue
AGLN60
ALEU79
ATYR80
APRO277
APHE278

site_idAD3
Number of Residues3
Detailsbinding site for residue GOL A 412
ChainResidue
ASER162
ATHR163
ASER164

site_idAD4
Number of Residues5
Detailsbinding site for residue GOL A 413
ChainResidue
ALEU292
AGLN296
BTYR263
BGLN267
BASP273

site_idAD5
Number of Residues5
Detailsbinding site for residue GOL A 414
ChainResidue
AGLY18
AHIS19
ATYR20
ALYS26
BTHR210

site_idAD6
Number of Residues7
Detailsbinding site for residue MES A 415
ChainResidue
AGLN186
ATYR212
AARG329
AXZ4403
ASO4408
AHEZ416
DDA17

site_idAD7
Number of Residues7
Detailsbinding site for residue HEZ A 416
ChainResidue
ATYR212
AVAL327
AALA328
AHIS338
AARG362
AMES415
AHOH506

site_idAD8
Number of Residues3
Detailsbinding site for residue MG B 401
ChainResidue
BASP128
BASP185
CDA19

site_idAD9
Number of Residues5
Detailsbinding site for residue SO4 B 402
ChainResidue
BLYS219
BARG222
BSER258
BPRO259
BVAL260

site_idAE1
Number of Residues3
Detailsbinding site for residue GOL B 403
ChainResidue
BARG222
BHOH506
BGLY218

site_idAE2
Number of Residues8
Detailsbinding site for residue GOL C 101
ChainResidue
AVAL260
ASO4405
CDC6
CDA7
CDT8
CHOH207
CHOH209
DDC11

site_idAE3
Number of Residues5
Detailsbinding site for residue SO4 D 101
ChainResidue
AARG229
AARG336
AHOH512
AHOH526
DDC16

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP123
AASP185
BASP123
BASP185

227344

PDB entries from 2024-11-13

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