5NO1

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ407 (compound 5g)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 401

Chain	Residue
A	ASP128
A	GLU221
A	XZ4403
D	HOH201

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 402

Chain	Residue
A	ASP128
A	ASP185
A	XZ4403
A	HOH515
A	HOH536

---

site_id	AC3
Number of Residues	16
Details	binding site for residue XZ4 A 403

Chain	Residue
A	ASP128
A	ASP185
A	TYR212
A	PRO214
A	GLN215
A	GLU221
A	MG401
A	MG402
A	SO4408
A	MES415
A	HOH515
A	HOH536
C	DG4
D	DC16
D	DA17
D	HOH201

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 404

Chain	Residue
A	HIS62
A	HIS66
A	CYS96
A	CYS99

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 405

Chain	Residue
A	ARG114
A	TYR303
A	PRO305
C	DC6
C	GOL101

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 406

Chain	Residue
A	PRO115
A	ASP116
C	DT3

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 A 407

Chain	Residue
A	SER136
A	GLN137
A	LYS241
A	HOH501

---

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 A 408

Chain	Residue
A	ASP185
A	GLN186
A	GLY187
A	PRO211
A	TYR212
A	XZ4403
A	MES415
A	HOH527

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 A 409

Chain	Residue
A	LYS228
A	SER332
A	LEU333
A	ARG336
A	HOH504

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 410

Chain	Residue
A	HIS338
A	LYS339
A	HIS357
A	HOH522

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL A 411

Chain	Residue
A	GLN60
A	LEU79
A	TYR80
A	PRO277
A	PHE278

---

site_id	AD3
Number of Residues	3
Details	binding site for residue GOL A 412

Chain	Residue
A	SER162
A	THR163
A	SER164

---

site_id	AD4
Number of Residues	5
Details	binding site for residue GOL A 413

Chain	Residue
A	LEU292
A	GLN296
B	TYR263
B	GLN267
B	ASP273

---

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL A 414

Chain	Residue
A	GLY18
A	HIS19
A	TYR20
A	LYS26
B	THR210

---

site_id	AD6
Number of Residues	7
Details	binding site for residue MES A 415

Chain	Residue
A	GLN186
A	TYR212
A	ARG329
A	XZ4403
A	SO4408
A	HEZ416
D	DA17

---

site_id	AD7
Number of Residues	7
Details	binding site for residue HEZ A 416

Chain	Residue
A	TYR212
A	VAL327
A	ALA328
A	HIS338
A	ARG362
A	MES415
A	HOH506

---

site_id	AD8
Number of Residues	3
Details	binding site for residue MG B 401

Chain	Residue
B	ASP128
B	ASP185
C	DA19

---

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 B 402

Chain	Residue
B	LYS219
B	ARG222
B	SER258
B	PRO259
B	VAL260

---

site_id	AE1
Number of Residues	3
Details	binding site for residue GOL B 403

Chain	Residue
B	ARG222
B	HOH506
B	GLY218

---

site_id	AE2
Number of Residues	8
Details	binding site for residue GOL C 101

Chain	Residue
A	VAL260
A	SO4405
C	DC6
C	DA7
C	DT8
C	HOH207
C	HOH209
D	DC11

---

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 D 101

Chain	Residue
A	ARG229
A	ARG336
A	HOH512
A	HOH526
D	DC16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"Integrase catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00457","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---