4Y5X
| Diabody 305 complex with EpoR | Descriptor: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, Erythropoietin receptor, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-03-18 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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4Y5V
| Diabody 305 complex with EpoR | Descriptor: | DI(HYDROXYETHYL)ETHER, Diabody 305 VL domain, Erythropoietin receptor, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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7UWL
| Structure of the IL-25-IL-17RB-IL-17RA ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWM
| Structure of the IL-17A-IL-17RA binary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWJ
| Structure of the homodimeric IL-25-IL-17RB binary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor B, Interleukin-25 | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWK
| Structure of the higher-order IL-25-IL-17RB complex | Descriptor: | Interleukin-17 receptor B, Interleukin-25 | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWN
| Structure of the IL-17A-IL-17RA-IL-17RC ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7TR4
| MA2-MART1-HLAA0201 | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA-A*02:01, ... | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-01-27 | Release date: | 2022-11-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nat.Biotechnol., 41, 2023
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3SE4
| human IFNw-IFNAR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.5001 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3S9D
| binary complex between IFNa2 and IFNAR2 | Descriptor: | CHLORIDE ION, Interferon alpha-2, Interferon alpha/beta receptor 2 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-01 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9999 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3SE3
| human IFNa2-IFNAR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha 2b, Interferon alpha/beta receptor 1, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4.0001 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3S98
| human IFNAR1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha/beta receptor 1 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-01 | Release date: | 2011-08-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3S8W
| D2 domain of human IFNAR2 | Descriptor: | CHLORIDE ION, Interferon alpha/beta receptor 2 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-05-31 | Release date: | 2011-08-31 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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6MOH
| Dimeric DARPin C_R3 complex with EpoR | Descriptor: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOI
| Dimeric DARPin C_angle_R5 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.065 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOJ
| Dimeric DARPin A_angle_R5 complex with EpoR | Descriptor: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOK
| Dimeric DARPin A_distance_R7 complex with EpoR | Descriptor: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (5.101 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOG
| Dimeric DARPin C_R3 | Descriptor: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOE
| Monomeric DARPin E2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOL
| Monoextended DARPin M_R12 complex with EpoR | Descriptor: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.163 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOF
| Monomeric DARPin G2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.894 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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