Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4W4X
DownloadVisualize
BU of 4w4x by Molmil
JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4V
DownloadVisualize
BU of 4w4v by Molmil
JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-Jun N-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4Y
DownloadVisualize
BU of 4w4y by Molmil
JNK2/3 in complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4W
DownloadVisualize
BU of 4w4w by Molmil
JNK2/3 in complex with N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide
分子名称: N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide, c-Jun N-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
1RF6
DownloadVisualize
BU of 1rf6 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase in S3P-GLP Bound State
分子名称: 5-enolpyruvylshikimate-3-phosphate synthase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF4
DownloadVisualize
BU of 1rf4 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase, Tetrahedral intermediate Bound State
分子名称: (3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 5-enolpyruvylshikimate-3-phosphate synthase
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF5
DownloadVisualize
BU of 1rf5 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase in Unliganded State
分子名称: 5-enolpyruvylshikimate-3-phosphate synthase
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
6N2U
DownloadVisualize
BU of 6n2u by Molmil
IL-8 Structure from Bacterial Expression Source
分子名称: Interleukin-8
著者Park, H, Jung, J.H, Luo, J.L.
登録日2018-11-14
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.254 Å)
主引用文献IL-8 Structure from Bacterial Expression Source
To Be Published
8EFJ
DownloadVisualize
BU of 8efj by Molmil
A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds
分子名称: (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Park, H, Feng, Y.
登録日2022-09-08
公開日2023-09-20
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds
To Be Published
1YPQ
DownloadVisualize
BU of 1ypq by Molmil
Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex
分子名称: 1,4-DIETHYLENE DIOXIDE, oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1N4E
DownloadVisualize
BU of 1n4e by Molmil
Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.-S, Kang, C.
登録日2002-10-30
公開日2003-02-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a DNA decamer containing a cis-syn thymine dimer.
Proc.Natl.Acad.Sci.USA, 99, 2002
3O3U
DownloadVisualize
BU of 3o3u by Molmil
Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)
分子名称: Maltose-binding periplasmic protein, Advanced glycosylation end product-specific receptor, SULFATE ION, ...
著者Park, H, Boyington, J.C.
登録日2010-07-26
公開日2010-10-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.497 Å)
主引用文献The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.
J.Biol.Chem., 285, 2010
3RF3
DownloadVisualize
BU of 3rf3 by Molmil
Shigella IpaA-VBS3 in complex with human vinculin
分子名称: CACODYLATE ION, Invasin ipaA, Vinculin
著者Park, H, Sharff, A, Izard, T.
登録日2011-04-05
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Novel vinculin binding site of the IpaA invasin of Shigella.
J.Biol.Chem., 286, 2011
5BTM
DownloadVisualize
BU of 5btm by Molmil
Crystal structure of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10)
分子名称: MAGNESIUM ION, RNA (55-mer), SODIUM ION
著者Park, H.
登録日2015-06-03
公開日2015-07-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.778 Å)
主引用文献Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).
Biochemistry, 54, 2015
3TJ5
DownloadVisualize
BU of 3tj5 by Molmil
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-N; residues 412-434) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, GLYCEROL, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
3TJ6
DownloadVisualize
BU of 3tj6 by Molmil
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
1SM5
DownloadVisualize
BU of 1sm5 by Molmil
Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*(BRU)P*TP*AP*AP*TP*(BRU)P*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.-S, Kang, C.
登録日2004-03-08
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of a DNA Decamer Containing a Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
1T4I
DownloadVisualize
BU of 1t4i by Molmil
Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.S, Kang, C.
登録日2004-04-29
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of a DNA Decamer Containing a cis-syn Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
1YPU
DownloadVisualize
BU of 1ypu by Molmil
Human Oxidized Low Density Lipoprotein Receptor LOX-1 C2 Space Group
分子名称: oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1YPO
DownloadVisualize
BU of 1ypo by Molmil
Human Oxidized Low Density Lipoprotein Receptor LOX-1 P3 1 21 Space Group
分子名称: oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
4WHZ
DownloadVisualize
BU of 4whz by Molmil
Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
分子名称: 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide, Mitogen-activated protein kinase 10
著者Park, H, LoGrasso, P.
登録日2014-09-24
公開日2014-11-26
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives.
J.Med.Chem., 57, 2014
7S1N
DownloadVisualize
BU of 7s1n by Molmil
N-Aromatic-Substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable JNK3 Inhibitors
分子名称: 4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide, Mitogen-activated protein kinase 10
著者Park, H.
登録日2021-09-02
公開日2021-11-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献N -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
8ENJ
DownloadVisualize
BU of 8enj by Molmil
Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide
著者Park, H, Mersal, K.I.
登録日2022-09-30
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Eur.J.Med.Chem., 261, 2023
4Y46
DownloadVisualize
BU of 4y46 by Molmil
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-10
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
DownloadVisualize
BU of 4y5h by Molmil
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-11
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.055 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015

218853

件を2024-04-24に公開中

PDB statisticsPDBj update infoContact PDBjnumon